DDOST
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Official Full Name
dolichyl-diphosphooligosaccharide--protein glycosyltransferase -
Overview
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. -
Synonyms
DDOST;dolichyl-diphosphooligosaccharide--protein glycosyltransferase;dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit;KIAA0115;MGC2191;OK/SW-cl.45;OST;OST48;WBP1;AGE R1;DDOST 48 kDa subunit;Dolichyl-diphosphooligosaccharide-protein glycosyltransferase;EC 2.4.1.119;Oligosaccharyl transferase 48 kDa subunit;RP23-25C1.4;wu:fa11d01;zgc:66068;zgc:77478;advanced glycation endproduct receptor 1;oligosaccharyltransferase 48 kDa subunit;dolichyl-diphosphooligosaccharide-protein glycotransferase;AGER1;OKSWcl45
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Bovine
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
DDOST involved in several pathways and played different roles in them. We selected most pathways DDOST participated on our site, such as AGE/RAGE pathway,Advanced glycosylation endproduct receptor signaling,Asparagine N-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDOST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Advanced glycosylation endproduct receptor signaling | LGALS3,SAA1,ALCAMB,S100A12,S100B,APPA,APPB,AGER |
| AGE/RAGE pathway | TIRAP,JUN,AGER,MAPK14,EGFR,ATF2,MMP13,LGALS3,DIAPH1,JAK2 |
| Immune System | ATP6V1G3,RNF34,CRP,FBXO27,CLEC2B,CLEC4A,BTR16,MB21D1,SLAMF6,LRSAM1 |
| Innate Immune System | CYLD,CD300E,HBL3,DEFB129,BTR29,TAX1BP1,MYO9B,POLR3F,TXNIPA,DEFB1 |
| Metabolism of proteins | RAB27A,OTOP2,GCNT3,TBCA,LTF,PHC2,IGFBP6A,GALNT5,ANKRD28,GATA6 |
| Gene Expression | GTF3AB,TSEN34,EEF1D,SUPT16H,GTF3A,MBD3B,METTL3,MTA3,MTERF,KHSRP |
| Asparagine N-linked glycosylation | CSNK1D,GOLGA2,AREG,LMAN2,SEC23IP,TRAPPC9,STT3A,YKT6,NAPB,ST6GALNAC2 |
| Metabolic pathways | PLA2G1B,AANAT1,NDUFA13,MMAB,ACSS2,CNDP1,NT5E,INPP1,SGPL1,PNP5A |
Protein Function
DDOST has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity,contributes_to oligosaccharyl transferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDOST itself. We selected most functions DDOST had, and list some proteins which have the same functions with DDOST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity | RPN2,TUSC3,DAD1,OSTC,STT3A,RPN1 |
| contributes_to oligosaccharyl transferase activity | DAD1 |
| protein binding | SPSB1,HMGB3,KCNIP1,GYS1,MAU2,LMX1B,ASB2,RAB3B,AGPAT4,GDPD5 |
Interacting Protein
DDOST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDOST here. Most of them are supplied by our site. Hope this information will be useful for your research of DDOST.
TMEM173;SEC27;copa_schpo;7242199;PGRMC1;SAP18;RFXANK;PTP4A3;TNFRSF1A;TNFRSF1B;MCC;HLA-B;MAGEA6;BRCC3;COP1;EIF6;ARF6;SMYD3;TMBIM4
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