DDIT3
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Official Full Name
DNA-damage-inducible transcript 3 -
Overview
GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and merabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites. -
Synonyms
DDIT3;DNA-damage-inducible transcript 3;DNA damage-inducible transcript 3 protein;C/EBP zeta;CHOP;CHOP10;GADD153;DDIT-3;c/EBP-homologous protein 10;CCAAT/enhancer-binding protein homologous protein;growth arrest and DNA damage-inducible protein GADD153;CEBPZ;CHOP-10;MGC4154
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- Human
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- GST&His
- Non
- Avi&Fc&His
Involved Pathway
DDIT3 involved in several pathways and played different roles in them. We selected most pathways DDIT3 participated on our site, such as ATF-2 transcription factor network,ATF4 activates genes,ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF6-alpha activates chaperone genes | KCNA3 |
| Metabolism of proteins | NAPG,OTOP2,FBXW2,B3GNT2A,TRAPPC2,CPB2,ST6GALNAC2,IGFBP5,GFER,EIF2B1 |
| ATF-2 transcription factor network | DUSP1,GADD45A,CDK4,JDP2,CREB1,CBFB,JUND,JUN,CSRP2,DUSP10 |
| Adipogenesis | NDN,PIANP,CISD1,GATA2,MBNL1,NR1H3,FRZB,GDF10,EPAS1B,BMP3 |
| ATF6-alpha activates chaperones | KCNA3,YY2 |
| MAPK signaling pathway | PPM1A,TP53,TGFB2,JUND,PPP5C,FGFR2,LAMTOR3,MAP2K2A,PPP3R1B,ELK4 |
| Non-alcoholic fatty liver disease (NAFLD) | PIK3R2,COX8C,NDUFS5,COX4I2,PRKAG3,INS2,SOCS3,NDUFA4,NDUFS8,PRKAA2 |
| ATF4 activates genes | EXOSC8,KCNA3,DCP2 |
Protein Function
DDIT3 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT3 itself. We selected most functions DDIT3 had, and list some proteins which have the same functions with DDIT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | EBF2,NKX2-8,PLSCR1,ATF2,KLF5,CEBPZ,ELF4,ONECUT3,FOXL2,TFAP2C |
| transcription regulatory region sequence-specific DNA binding | NONO,NR5A1,PER2,KDM3A,EPAS1B,BACH1B,POU5F1,PSPC1,ATF3,NFE2L2 |
| protein binding | ATP4B,TMEM11,CA,CHRNA5,KCNH2,C15orf57,RGS1,Ctsl,GOSR2,PNMA5 |
| transcription factor binding | FOXA1,HTT,NIF3L1,MYOCD,JUNBB,SRF,TRIM6,PPP1R13BA,PDX1,TRERF1 |
| protein heterodimerization activity | CLNS1A,SMAD4,RXRA,ZHX3,BCL2L2,SNX2,KCNB1,SOX8,H3F3B.1,CYBB |
| cAMP response element binding protein binding | CRTC1A,CREB3,CREM,CRTC3,ATF2,CRTC1,CRTC2,DAPK3,KCNA3 |
| leucine zipper domain binding | MKL1,KCNA3,ATF4,NRL,DAPK3,PMF1,PAWR,AATF,CRX,ERC1 |
| DNA binding | OTPA,GON4L,HMGB2,ESRRGA,FOXE1,ZNF280D,SP9,E4F1,ZFP768,EME2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | AEBP2,OTX2,TFAP2E,BATF,ELK3,ZNF264,POU3F2,MYOD1,CHD7,KLF17 |
Interacting Protein
DDIT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT3.
CEBPG;BATF;DBP;BACH1;CREB3;FOS;HBZ;ATF2;FOSL2;JUNB;ATF7;CEBPB;ATF3
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References
- Richards, M; Phoon, CW; et al. A New Class of Pluripotent Stem Cell Cytotoxic Small Molecules. PLOS ONE 9:-(2014).
- Carvalheira, GM; Nozima, BHN; et al. DDIT3, STT3A (ITM1), ARG2 and FAM129A (Niban, C1orf24) in diagnosing thyroid carcinoma: variables that may affect the performance of this antibody-based test and promise. MODERN PATHOLOGY 26:611-613(2013).
