DCP2
- Product List
- Overview
- Review / Q&A
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Official Full Name
decapping mRNA 2 -
Overview
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] -
Synonyms
DCP2;decapping mRNA 2;NUDT20;m7GpppN-mRNA hydrolase;hDpc;mRNA-decapping enzyme 2;DCP2 decapping enzyme homolog;nudix (nucleoside diphosphate linked moiety X)-type motif 20
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DCP2-11861H | Recombinant Human DCP2 protein, His-tagged | E.coli | Human | His | 1-385aa | |
| DCP2-10499Z | Recombinant Zebrafish DCP2 | Mammalian Cells | Zebrafish | His |
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| DCP2-1193R | Recombinant Rhesus monkey DCP2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| DCP2-1570H | Recombinant Human DCP2 protein | E.coli | Human | Non |
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| DCP2-2402H | Recombinant Human DCP2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DCP2-1018R | Recombinant Rhesus Macaque DCP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| DCP2-1690H | Recombinant Human DCP2 Protein (1-385 aa), His-tagged | Yeast | Human | His | 1-385 aa |
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| DCP2-2893HF | Recombinant Full Length Human DCP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 385 amino acids |
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Involved Pathway
DCP2 involved in several pathways and played different roles in them. We selected most pathways DCP2 participated on our site, such as ATF4 activates genes,Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA,Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | ZFP36L1,ZFP36L1B,ZFP36L1A,MAPKAPK2B,EXOSC8 |
| KSRP (KHSRP) binds and destabilizes mRNA | KHSRP,EXOSC8 |
| Deadenylation-dependent mRNA decay | EIF4A1,EIF4A2,DCP1B,NT5C3B,PAIP1,EIF4E,D1BWG0212E,EIF4G1,LSM6,DDX6 |
| Metabolism of proteins | PFDN4,GRPEL1,TIMM17A,PAPPA2,IGFBP1A,ADAMTS3,TPP1,IGFBP5,TIMM23,SLC30A6 |
| RNA degradation | TOB2,CNOT4,SKIV2L2,CNOT6L,LSM3,DCP1B,DHX36,ENO1B,LSM4,EXOSC5 |
| Gene Expression | ADAT1,COBRA1,TET2,TBX5,ZFP143,ZNF253,KIAA1456,ZNF224,EEF2,ZNF688 |
| PERK regulates gene expression | EXOSC8 |
| ATF4 activates genes | KCNA3,DDIT3,EXOSC8 |
Protein Function
DCP2 has several biochemical functions, for example, RNA binding,exoribonuclease activity, producing 5-phosphomonoesters,m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCP2 itself. We selected most functions DCP2 had, and list some proteins which have the same functions with DCP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| manganese ion binding | PCK1,TDP2,FEN1,HMGCL,LAP3,DYRK2,PPM1A,PPM1M,PIM1,XPNPEP3 |
| RNA binding | RPL6,CPSF1,SNRPF,MOV10B.1,D19BWG1357E,NR0B1,PTBP1B,HSP90B1,AGFG1A,RPL9 |
| protein binding | RAMP2,ARHGAP33,APOBEC3G,HSPE1,RAB4B,MUTYH,GTPBP3,PPP4R2,KCNQ5,CDC42BPG |
| m7G(5)pppN diphosphatase activity | NUDT16,DCPS |
Interacting Protein
DCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCP2.
DCP1A;UPF1;EDC4;Edc4;DCP1B
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