DCP2

  • Official Full Name

    decapping mRNA 2

  • Overview

    The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

  • Synonyms

    DCP2;decapping mRNA 2;NUDT20;m7GpppN-mRNA hydrolase;hDpc;mRNA-decapping enzyme 2;DCP2 decapping enzyme homolog;nudix (nucleoside diphosphate linked moiety X)-type motif 20

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • Yeast
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DCP2-11861H Recombinant Human DCP2 protein, His-tagged E.coli Human His 1-385aa
DCP2-10499Z Recombinant Zebrafish DCP2 Mammalian Cell Zebrafish His
DCP2-1193R Recombinant Rhesus monkey DCP2 Protein, His-tagged Mammalian Cell Rhesus macaque His
DCP2-1570H Recombinant Human DCP2 protein E.coli Human Non
DCP2-2402H Recombinant Human DCP2 Protein, GST-tagged Wheat Germ Human GST
DCP2-446HCL Recombinant Human DCP2 cell lysate Human Non
DCP2-1018R Recombinant Rhesus Macaque DCP2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DCP2-1018R-B Recombinant Rhesus Macaque DCP2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DCP2-1690H Recombinant Human DCP2 Protein (1-385 aa), His-tagged Yeast Human His 1-385 aa
DCP2-2893HF Recombinant Full Length Human DCP2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 385 amino acids

    Involved Pathway

    DCP2 involved in several pathways and played different roles in them. We selected most pathways DCP2 participated on our site, such as ATF4 activates genes,Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA,Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF4 activates genes DDIT3,KCNA3,EXOSC8
    Metabolism of proteins RING1,SPCS3,MIA3,EIF4H,EXOC3,NOP56,HDGF,APEH,MFGE8,PAPPA
    Gene Expression RRAGB,CDKAL1,TSEN54,DNAJC8,AARS,RBB4L,ZNF559,MBD3A,ARHGEF38,ZNF234
    Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA ZFP36L1B,EXOSC8,MAPKAPK2B,ZFP36L1A,ZFP36L1
    KSRP (KHSRP) binds and destabilizes mRNA EXOSC8,KHSRP
    RNA degradation EDC3,ENO1A,TOB1B,CNOT6L,GM5506,BTG4,PAPD7,DHX36,PFKMB,PFKP
    PERK regulates gene expression EXOSC8
    Deadenylation-dependent mRNA decay EIF4G1,DCP1B,NT5C3B,EXOSC8,DDX6,EIF4A1,D1BWG0212E,LSM6,EIF4B,EIF4A2

    Protein Function

    DCP2 has several biochemical functions, for example, RNA binding,exoribonuclease activity, producing 5-phosphomonoesters,m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCP2 itself. We selected most functions DCP2 had, and list some proteins which have the same functions with DCP2. You can find most of the proteins on our site.

    Function Related Protein
    manganese ion binding CDIPT,GALNT3,WRN,PPM1BA,NUDT16,PPM1B,SLC11A2,FAM20C,PPEF1,PEPD
    protein binding SART3,FBXO34,CP110,CASP7,SNAPC5,SUSD2,VPS29,CCDC59,NCBP2,MICU1
    RNA binding IFIT12,RBMY1F,FARSB,IGHMBP2,PCBP4,Aff2,SRP14,IFIT3,SMN1,PSMA1
    m7G(5)pppN diphosphatase activity NUDT16,DCPS

    Interacting Protein

    DCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCP2.

    DCP1A;UPF1;EDC4;Edc4;DCP1B

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