DCLRE1C

  • Official Full Name

    DNA cross-link repair 1C

  • Overview

    This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5-3 exonuclease activity; it also exhibits endonuclease activity on 5 and 3 overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

  • Synonyms

    DCLRE1C;DNA cross-link repair 1C;SCIDA;SNM1C;A-SCID;RS-SCID;DCLREC1C;protein artemis;SNM1 homolog C;SNM1-like protein;severe combined immunodeficiency, type a (Athabascan);DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DCLRE1C-2932H Recombinant Human DCLRE1C protein, His-tagged E.coli Human His 305-577 aa
DCLRE1C-1192R Recombinant Rhesus monkey DCLRE1C Protein, His-tagged Mammalian Cell Rhesus macaque His
DCLRE1C-1796R Recombinant Rat DCLRE1C Protein Mammalian Cell Rat His
DCLRE1C-2396H Recombinant Human DCLRE1C Protein, GST-tagged Wheat Germ Human GST
DCLRE1C-3234C Recombinant Chicken DCLRE1C Mammalian Cell Chicken His
DCLRE1C-4147Z Recombinant Zebrafish DCLRE1C Mammalian Cell Zebrafish His
DCLRE1C-7049HCL Recombinant Human DCLRE1C 293 Cell Lysate HEK293 Human Non
DCLRE1C-1017R Recombinant Rhesus Macaque DCLRE1C Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
DCLRE1C-1017R-B Recombinant Rhesus Macaque DCLRE1C Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DCLRE1C-1454R Recombinant Rat DCLRE1C Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
DCLRE1C-1454R-B Recombinant Rat DCLRE1C Protein Pre-coupled Magnetic Beads HEK293 Rat
DCLRE1C-2881HF Recombinant Full Length Human DCLRE1C Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 434 amino acids

    Involved Pathway

    DCLRE1C involved in several pathways and played different roles in them. We selected most pathways DCLRE1C participated on our site, such as Non-homologous end-joining,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLRE1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary i BLNK,TAP2,ZAP70,IL2RG,CD8B,CD4,CD19,CD3D,ICOS,CD8A
    nodeficiency AIRE,TAP1,CD19,CD4,RAG2,CD8B,RFXANK,CD8B1,CD3D,CD3E
    Non-homologous end-joining POLL,XRCC4,POLM,PRKDC,FEN1,DNTT,MRE11A,NHEJ1,XRCC5,LIG4

    Protein Function

    DCLRE1C has several biochemical functions, for example, 5-3 exodeoxyribonuclease activity,5-3 exonuclease activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLRE1C itself. We selected most functions DCLRE1C had, and list some proteins which have the same functions with DCLRE1C. You can find most of the proteins on our site.

    Function Related Protein
    5-3 exodeoxyribonuclease activity EXO1,DCLRE1A
    protein binding SOX13,BCL7A,RCN1,PHB,NUDT14,TBC1D14,USP22,CD74,CCDC135,FAM103A1
    damaged DNA binding BRCA1,TP73,TP53,RPA2,FEN1,RAD23A,POLI,PNKP,POLK,RPA3
    endonuclease activity CL2,RNASE3,RNASE2,EAR5,FEN1,DNASE2A,MRE11A,EXOG,APEX1,RNASE6
    5-3 exonuclease activity EXO1,DOM3Z,FAN1,DXO,FEN1,POLN,CPSF3,XRN2
    single-stranded DNA endodeoxyribonuclease activity ERCC4,RBBP8,MRE11A,SETMAR

    Interacting Protein

    DCLRE1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLRE1C here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLRE1C.

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