DBNL
-
Official Full Name
drebrin-like -
Overview
Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. -
Synonyms
DBNL;drebrin-like;ABP1;HIP55;SH3P7;HIP-55;drebrin-like protein;drebrin-F;cervical SH3P7;SH3 domain-containing protein 7;cervical mucin-associated protein;HPK1-interacting protein of 55 kDa;src homology 3 domain-containing protein HIP-55
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Human cells
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- Insect Cell
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
DBNL involved in several pathways and played different roles in them. We selected most pathways DBNL participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBNL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCR Signaling Pathway | CD83 |
| Apoptosis | AKT2,MAP3K14,CASP10,NFKB1,CASP7,PIK3R3A,ENDOG,YWHAQ,PIK3R5,PIK3R3 |
| Programmed Cell Death | GZME,GZMF,STK24,HMGB2A,PLECA,DNM1L,STK24B,SATB1,GAS2,DAPK1 |
| JNK signaling in the CD4+ TCR pathway | MAP4K1 |
| Apoptotic execution phase | HIST1H1E,STK26,HIST1H1A,DNM1L,DBNLA,STK24,DSG2,HMGB2A,CLSPN,CASP6L2 |
| Apoptotic cleavage of cellular proteins | CASP6L1,PLECA,OCLN,LMNB1,CASP8L1,BCAP31,STK24,CLSPN,SATB1,DSG1 |
| Caspase-mediated cleavage of cytoskeletal proteins | DBNLA,GAS2,DBNLB,PLEC,ADD1,SPNA2,CASP6L1,CASP6L2,PLECA,VIML |
| TCR signaling in naive CD4+ T cells | SLA2,STK39 |
Protein Function
DBNL has several biochemical functions, for example, actin binding,actin filament binding,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DBNL itself. We selected most functions DBNL had, and list some proteins which have the same functions with DBNL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DTX2,MPPE1,SCP2,CD47,RG9MTD1,MDM4,MTNR1A,ENTPD3,GRID2IP,HPCAL4 |
| actin binding | INF2,DST,MPRIP,WIPF1A,ACTN3B,SCINLB,GAS2L3,MYH9,EPB41,TMSB |
| protein C-terminus binding | SDCBP,RABAC1,AXIN1,ABL1,TBL1X,MPDZ,AP2A1,FIGN,SP1,TOP2B |
| protein domain specific binding | RAPGEF3,IGBP1,SP100,CALM,STAMBP,PRKAR2B,STX1B,UNC13A,HIST2H4A,AIDA |
| actin filament binding | VIL1,EGFR,CTNNAL1,JUB,ACTN2B,WIPF2B,SMYHC2,ERMN,SVILA,AIF1 |
| enzyme activator activity | TAB1,ARL1,MMP15,HSPB2,MGST2,ASAP2,SFTPB,ALOX5AP,APOA5,DCP1A |
Interacting Protein
DBNL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBNL here. Most of them are supplied by our site. Hope this information will be useful for your research of DBNL.
SH2D4A;SH3BP2;SH2D4A;ACD;HERC2
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References
- Li, ZJ; Park, HR; et al. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. ONCOTARGET 5:3197-3209(2014).
- Liu, N; Xing, R; et al. HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway. MOLECULAR BIOSYSTEMS 10:1932-1939(2014).
