DBN1
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Official Full Name
Drebrin 1 -
Overview
Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites. Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the adult brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine. -
Synonyms
DBN1;drebrin 1;drebrin;drebrin E;drebrin-1;drebrin E2;developmentally-regulated brain protein;DKFZp434D064;D0S117E;OTTHUMP00000161448;OTTHUMP00000161449;OTTHUMP00000165798;OTTHUMP00000223806
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DBN1-1781R | Recombinant Rat DBN1 Protein | Mammalian Cell | Rat | His |
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| DBN1-2369H | Recombinant Human DBN1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DBN1-28133TH | Recombinant Human DBN1, His-tagged | E.coli | Human | His | 289-467 a.a. |
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| DBN1-4319M | Recombinant Mouse DBN1 Protein | Mammalian Cell | Mouse | His |
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| DBN1-7048C | Recombinant Chicken DBN1 | Mammalian Cell | Chicken | His |
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| DBN1-217HCL | Recombinant Human DBN1 lysate | HEK293 | Human | Non |
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| DBN1-1439R | Recombinant Rat DBN1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DBN1-1439R-B | Recombinant Rat DBN1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DBN1-1926H | Recombinant Human DBN1 Protein (Gly3-Ser134), His tagged | E.coli | Human | His | Gly3-Ser134 |
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| DBN1-2210M | Recombinant Mouse DBN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DBN1-2210M-B | Recombinant Mouse DBN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DBN1-2567HF | Recombinant Full Length Human DBN1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 649 amino acids |
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| DBN1-672H | Recombinant Human DBN1 Protein, His-tagged | E.coli | Human | His | Gly3~Ser134 |
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Involved Pathway
DBN1 involved in several pathways and played different roles in them. We selected most pathways DBN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DBN1 has several biochemical functions, for example, DNA binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DBN1 itself. We selected most functions DBN1 had, and list some proteins which have the same functions with DBN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ARHGEF38,ZNF434,RFX2,SOX15,HIST1H2AM,LEF1,POLD2,SPZ1,C19orf40,ZNF75A |
| contributes_to ubiquitin-protein transferase activity | CCIN,KBTBD6,KEAP1A,KLHL5,KLHL40A,KLHL22,DTL,KLHDC7A,RBX1,KBTBD10 |
Interacting Protein
DBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DBN1.
CXCR4;GRB2;Mllt4;MLLT4;PTEN
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References
- Bhat, NR; Thirumangalakudi, L; et al. Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet. JOURNAL OF ALZHEIMERS DISEASE 36:781-789(2013).
- Suh, HN; Kim, MO; et al. Laminin-111 Stimulates Proliferation of Mouse Embryonic Stem Cells Through a Reduction of Gap Junctional Intercellular Communication via RhoA-Mediated Cx43 Phosphorylation and Dissociation of Cx43/ZO-1/Drebrin Complex. STEM CELLS AND DEVELOPMENT 21:2058-2070(2012).
