DARS2
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Official Full Name
aspartyl-tRNA synthetase 2, mitochondrial -
Overview
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). -
Synonyms
DARS2;aspartyl-tRNA synthetase 2, mitochondrial;aspartyl-tRNA synthetase, mitochondrial;aspartate tRNA ligase 2;mitochondrial;FLJ10514;Aspartate tRNA ligase;Aspartyl tRNA synthetase 2 (mitochondrial);AspRS;LBSL;MT ASPRS;RP3 383J4.2;aspartate tRNA ligase 2, mitochondrial;MT-ASPRS;RP3-383J4.2
Recombinant Proteins
- Rat
- Human
- Bovine
- Mouse
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- E.coli
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
DARS2 involved in several pathways and played different roles in them. We selected most pathways DARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | PET112L,GATC,CARS,VARS,TARS,YARS,PSTK,AARS2,MADD,QRSL1 |
Protein Function
DARS2 has several biochemical functions, for example, ATP binding,aspartate-tRNA ligase activity,aspartate-tRNA(Asn) ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARS2 itself. We selected most functions DARS2 had, and list some proteins which have the same functions with DARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aspartate-tRNA ligase activity | DARS |
| tRNA binding | IGHMBP2,IFIT5,ALKBH8,XPO5,CTU1,AARS,METTL1,RARS,AIMP1,TYW5 |
| protein binding | TF,KIAA1199,DDR2,SPARC,VIPAS39,SPATA13,PPHLN1,ZNF26,MGP,RICTOR |
| ATP binding | RIPK1,NUAK2,MOV10B.2,PRKCQ,TAP1,FLT4,DDX19B,PTK7,PRKACBA,PHKG1A |
| protein homodimerization activity | VEGFA,CPNE1,PEX11B,STUB1,PRMT8,TPD52L1,NRBP1,BMP7A,CEBPB,USH2A |
Interacting Protein
DARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DARS2.
EPHA8;DPYSL5;ssdna_dtdc;N
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