DARS

  • Official Full Name

    aspartyl-tRNA synthetase

  • Overview

    Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases.Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis.

  • Synonyms

    DARS;aspartyl-tRNA synthetase;aspartate--tRNA ligase, cytoplasmic;aspartate tRNA ligase 1;cytoplasmic;aspRS;aspartate tRNA ligase 1, cytoplasmic;aspartyl-tRNA synthetase, cytoplasmic;cell proliferation-inducing protein 40;cell proliferation-induc

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • GST
  • His
  • His&T7
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
DARS-11831H Recombinant Human DARS, GST-tagged E.coli Human GST 155-501a.a.
DARS-1666C Recombinant Chicken DARS Mammalian Cell Chicken His
DARS-2348H Recombinant Human DARS Protein, GST-tagged Wheat Germ Human GST
Dars-3671R Recombinant Rat Dars, His-tagged E.Coli or Yeast Rat His 501
DARS-3672H Recombinant Human DARS, His-tagged E.Coli or Yeast Human His 501
DARS-4805Z Recombinant Zebrafish DARS Mammalian Cell Zebrafish His
DARS-564H Recombinant Human DARS protein(Met1-Pro501), His-tagged E.coli Human His Met1-Pro501
DARS-8220H Recombinant Human DARS protein, His & T7-tagged E.coli Human His&T7 Gly363~Pro501
DARS-7073HCL Recombinant Human DARS 293 Cell Lysate HEK293 Human Non
DARS-1920H Recombinant Human DARS Protein (Gly363-Pro501), His tagged E.coli Human His Gly363-Pro501
DARS-2391H Recombinant Human DARS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Dars-2455M Recombinant Mouse Dars Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DARS-2514HF Recombinant Full Length Human DARS Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 501 amino acids

    Involved Pathway

    DARS involved in several pathways and played different roles in them. We selected most pathways DARS participated on our site, such as Alanine and aspartate metabolism,Aminoacyl-tRNA biosynthesis,Cytosolic tRNA aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alanine and aspartate metabolism ABAT,AGXT
    Cytosolic tRNA aminoacylation AIMP2,KARS,AARS,EEF1E1,FARSB,MADD,AIMP1
    tRNA Aminoacylation AIMP1,KARS,EEF1E1,FARS2,MADD,AARS,AIMP2,FARSB,WARS2,EARS2
    Gene Expression EEF2,NR6A1A,ZNF157,GATAD2B,ZNF221,ZNF490,TNKS1BP1,LSM11,ZNF225,RBM5
    Aminoacyl-tRNA biosynthesis FARSB,MARS,WARS,DARS2,WARS2,FARSA,GATC,RARS,NARS2,SEPSECS

    Protein Function

    DARS has several biochemical functions, for example, ATP binding,aminoacylase activity,aspartate-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARS itself. We selected most functions DARS had, and list some proteins which have the same functions with DARS. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MYLK4,DDR2,MAP2K4A,HSPA7,ACTC1A,ABCF1,CSNK1DA,KIF4,ABCB10,CKMT1A
    protein binding DOK3,FKBP3,TRAF5,PBX4,IGBP1,NANOS2,GSTO1,LIG3,RPL13,KATNAL1
    aspartate-tRNA ligase activity DARS2
    poly(A) RNA binding HIST1H4C,HNRPLL,PKM,SLIRP,MRPL32,RPL27,FAM103A1,SRSF4,BICC1,BRIX1
    aminoacylase activity ACY3,ASPA,ACY1,CAT

    Interacting Protein

    DARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARS here. Most of them are supplied by our site. Hope this information will be useful for your research of DARS.

    AIMP2;GRB2;gag;MAP3K7;PIK3R1;NDRG1;TNFRSF10D;HSP90AA1;yndJ;PIK3R3;15-deoxy-delta(12,14

    Resources

    References

    • Kozak, KR; Tsai, SP; et al. Total Antibody Quantification for MMAE-Conjugated Antibody-Drug Conjugates: Impact of Assay Format and Reagents. BIOCONJUGATE CHEMISTRY 24:772-779(2013).
    • Brenke, R; Hall, DR; et al. Application of asymmetric statistical potentials to antibody-protein docking. BIOINFORMATICS 28:2608-2614(2012).

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