DAB2
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Official Full Name
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -
Overview
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
DAB2;Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila);DOC2;DOC-2;disabled homolog 2;differentially-expressed protein 2;disabled homolog 2, mitogen-responsive phosphoprotein
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
DAB2 involved in several pathways and played different roles in them. We selected most pathways DAB2 participated on our site, such as Endocytosis,Formation of annular gap junctions,Gap junction degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction trafficking and regulation | GJB7,GJB5,MYO6B,CX27.5,GJD3,GJA5,MYO6A,GJB4,GJA4,GJC1 |
| Endocytosis | IST1,MDM2,ACAP2,CAV1,ARPC5LB,VPS36,PARD6A,VPS35,TRAF6,RHOA |
| Membrane Trafficking | ANKRD28,TRAPPC4,TRAPPC6BL,EXOC3,SNAPIN,RALAB,EXOC1,CPD,ARCN1,CNIH |
| TGF-beta Receptor Signaling Pathway | JUNBA,SNIP1,NFYBB,SKIA,MEF2AA,VDRB,CTCF,RUNX2A,EID2,STRAP |
| Gap junction degradation | MYO6A,MYO6,MYO6B |
| Gap junction trafficking | GJB2,MYO6B,GJA8,GJD3,GJA5,MYO6A,GJB7,GJB3,GJB5,GJC1 |
| TGF-beta receptor signaling | EIF2A,STRAP,TGFBR3 |
Protein Function
DAB2 has several biochemical functions, for example, SMAD binding,cargo receptor activity,clathrin adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DAB2 itself. We selected most functions DAB2 had, and list some proteins which have the same functions with DAB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| clathrin adaptor activity | LDLRAP1,PICALM,ARRB1 |
| protein C-terminus binding | CEP120,C11orf60,PEX16,KCNK3,DYNLL1,CTGF,MSH2,AXIN1,PHB2,VGLL2 |
| SMAD binding | SOD3,FOXH1,YY1,CTNNB1,EP300,TGFBRAP1,COL3A1,SKOR1,TGFBR2,ACVR1B |
| protein binding | CCT4,RAB7A,RPL23,HAND1,MXD3,IQUB,ANKRD17,PFN1,USP4,TMEM171 |
Interacting Protein
DAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAB2.
GRB2;MYO6;LRP6
Resources
Research Area
Adaptor ProteinsWnt Signaling Modulators
Caveolin-mediated Endocytosis
Clathrin-mediated Endocytosis
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References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Gao, S; Bajrami, I; et al. Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling. CANCER RESEARCH 74:5866-5877(2014).
