Camk1
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Official Full Name
calcium/calmodulin-dependent protein kinase I -
Overview
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. -
Synonyms
CAMK1;calcium/calmodulin-dependent protein kinase I;calcium/calmodulin-dependent protein kinase type 1;CaMKI;caM-KI;caMKI-alpha;caM kinase I alpha;MGC120317;MGC120318
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- E.coli
- Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Camk1 involved in several pathways and played different roles in them. We selected most pathways Camk1 participated on our site, such as Oxytocin signaling pathway,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Camk1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxytocin signaling pathway | ACTG1,CAMK2D,CACNB4,OXTR,CACNB2,GNAI1,NOS3,CALM4,PRKACA,PLA2G4A |
| Aldosterone synthesis and secretion | STAR,ATF4,DDX1,PLCB2,CYP21A1,PRKD3,ADCY6,SLC14A2,PRKACB,HSD3B1 |
Protein Function
Camk1 has several biochemical functions, for example, ATP binding,calmodulin binding,calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Camk1 itself. We selected most functions Camk1 had, and list some proteins which have the same functions with Camk1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | ADCY1,PPP3CC,PLCB1,SPHK1,ATPIF1,MAPKAPK2A,CAMKVB,MKNK2B,ITPKA,USP6 |
| calmodulin-dependent protein kinase activity | MKNK2A,MAPKAPK2B,CAMK2D1,CAMK2B1,CAMK1G,ITPKA,CAMK2D,NETO2,PTK2B,MYLK3 |
| protein binding | HSPB11,ALDH18A1,HSF1,KIAA1737,LARP7,MEP1A,CGA,Trl,CRMP1,PID1 |
| ATP binding | DNAJA2L,C9orf96,SBK1,P2RX8,Abcb1b,MYO5A,DHX32,RECQL,CMPK2,NUAK2 |
Interacting Protein
Camk1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Camk1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Camk1.
HSPB1;PIK3R3;CDK14;Mad2l1bp
Resources
Research Area
Calcium-binding Proteins and Related MoleculesIntracellular Kinases in the Akt Pathway
CaM Kinases
Wnt Intracellular Signaling
Intracellular Signaling Molecules in Angiogenesis
Related Services
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References
- Hidalgo, CG; Chung, CS; et al. The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKII delta) phosphorylates cardiac titin's spring elements. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 54:90-97(2013).
- Sugiyama, Y; Murao, K; et al. Calcium/calmodulin-dependent protein kinase IV involvement in the pathophysiology of glucotoxicity in rat pancreatic beta-cells. METABOLISM-CLINICAL AND EXPERIMENTAL 60:145-153(2011).
