CYP7A1
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Official Full Name
cytochrome P450, family 7, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010] -
Synonyms
CYP7A1;cytochrome P450, family 7, subfamily A, polypeptide 1;CP7A;CYP7;CYPVII;cholesterol 7-alpha-monooxygenase;cytochrome P450 7A1;cholesterol 7-alpha-hydroxylase;cytochrome P450, subfamily VIIA polypeptide 1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CYP7A1 involved in several pathways and played different roles in them. We selected most pathways CYP7A1 participated on our site, such as Bile acid and bile salt metabolism,Bile secretion,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile acid and bile salt metabolism | AKR1C2,AKR1C4,NCOA2,CYP27A1,Alb,CYP46A1,AKR1C6,ACOT8,SLC27A2A,CYP8B2 |
| Bile secretion | ATP1B1,AQP1,AQP9,FXYD2,HMGCR,ABCC3,AQP8,ABCG8,ATP1B4,ATP1A4 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT12,CCNC,AGPAT6,ACOT11B,ACSF2,TIAM2,CDK8,MED25,MED9,ACOT9.2 |
| Biological oxidations | SLC35B2,CYP3A7,CYP27A1,CYP1A2,NAT2,GGT6,CYP46A1,UGT1B7,PAOX,CYP2C18 |
| Drug Induction of Bile Acid Pathway | ABCC2,NR1I3,SLC51B,SLCO1B1,NR1I2 |
| Metabolic pathways | COMTB,AMY1A,GATC,CYP4A10,PANK2,TH,HSD17B12B,SPHK2,MAN2A1,AKR1B10 |
| Cytochrome P450 - arranged by substrate type | CYP46A1,CYP2A13,CYP2V1,CYP2E1,CYP3A7-CYP3AP1,CYP2C9,CYP8B2,CYP2K16,CYP2W1,CYP3C4 |
| Endogenous sterols | FDX1,CYP1B1,FDX1L,CYP17A1,CYP11B2,CYP21A2,CYP27A1,CYP11B1,CYP11A1,CYP8B2 |
Protein Function
CYP7A1 has several biochemical functions, for example, cholesterol 7-alpha-monooxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7A1 itself. We selected most functions CYP7A1 had, and list some proteins which have the same functions with CYP7A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | SCD,HBA2,CYP2C9,EGLN1,CYP51,CYP2AA2,CYP1D1,P4HA2,CYP19A1A,CYP3A5 |
| cholesterol 7-alpha-monooxygenase activity | CYP7A1A |
| heme binding | EPX,CYP2K18,CYP2K17,CYP2D6,CYP27C1,CYP2K19,CYP19A1,CYP1A1,CYP11C1,CYP2C39 |
Interacting Protein
CYP7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7A1.
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References
- Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
- Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).
