CYP4A11
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Official Full Name
cytochrome P450, family 4, subfamily A, polypeptide 11 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008] -
Synonyms
CYP4A11;cytochrome P450, family 4, subfamily A, polypeptide 11;CP4Y;CYP4A2;CYP4AII;cytochrome P450 4A11;CYPIVA11;P450HL-omega;20-HETE synthase;alkane-1 monooxygenase;cytochrome P450HL-omega;cytochrome P-450HK-omega;fatty acid omega-hydroxylase;lauric acid omega-hydroxylase;20-hydroxyeicosatetraenoic acid synthase;cytochrome P450, subfamily IVA, polypeptide 11
Recombinant Proteins
- Human
- Cynomolgus
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- GST
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP4A11-11787H | Recombinant Human CYP4A11, GST-tagged | E.coli | Human | GST | N-term-215a.a. | |
| CYP4A11-2280H | Recombinant Human CYP4A11 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP4A11-26692TH | Recombinant Human CYP4A11 | Wheat Germ | Human | Non | 216 amino acids |
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| CYP4A11-445C | Recombinant Cynomolgus CYP4A11 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| CYP4A11-439HCL | Recombinant Human CYP4A11 cell lysate | Human | Non |
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| CYP4A11-107HF | Recombinant Full Length Human CYP4A11 Protein | In Vitro Cell Free System | Human | Full L. 216 amino acids |
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| CYP4A11-191C | Recombinant Cynomolgus Monkey CYP4A11 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| CYP4A11-191C-B | Recombinant Cynomolgus Monkey CYP4A11 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| CYP4A11-2440HF | Recombinant Full Length Human CYP4A11 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 215 amino acids |
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| CYP4A11-73H | Active Recombinant Human CYP4A11 Protein | E.coli | Human |
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| CYP4A11-84H | Active Recombinant Human CYP4A11 Protein | E.coli | Human |
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Involved Pathway
CYP4A11 involved in several pathways and played different roles in them. We selected most pathways CYP4A11 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid, triacylglycerol, and ketone body metabolism | G0S2,ACOT9.2,SLC25A1A,PLIN2,MED26,AGPAT2,MED18,MED31,ACSF2,PPARGC1B |
| Fatty Acid Omega Oxidation | ADH1A,ADH6,ADH4,CYP2D6,ADH1B,CYP2A6,CYP2E1,ADH7,ADH1C,CYP1A1 |
| Biological oxidations | ACY3.1,SULT1ST5,UGT1B4,CYP1B1,CYP8B2,CYP3A4,CYP26A1,Sult2a6,FAM84B,CYP2AD6 |
| Eicosanoids | CYP4F22,CYP4B1,CYP4F11,CYP4F12 |
| Cytochrome P450 - arranged by substrate type | CYP3A5,CYP2K6,CYP2C9,CYP2Y3,CYP2F1,CYP2D6,CYP7A1,CYP1B1,CYP11B2,CYP27B1 |
| Fatty acids | CYP2D6,CYP2B6,CYP2A7,CYP4T8,CYP4F11,CYP2N13,CYP4F22,CYP2F1,CYP2V1,CYP2AD6 |
| Fatty acid degradation | ALDH9A1A.1,ADH7,ACSL1,ACSBG2,ACSL1B,ACSL3,ADH1B,ACADSB,ACOX3,ALDH1B1 |
| Arachidonic acid metabolism | CYP2E1,ALOX12E,PTGES3B,AKR1C3,CYP2P10,CYP2J6,GGT5A,PTGDS,GGT1A,DPEP1 |
Protein Function
CYP4A11 has several biochemical functions, for example, alkane 1-monooxygenase activity,arachidonic acid epoxygenase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4A11 itself. We selected most functions CYP4A11 had, and list some proteins which have the same functions with CYP4A11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | HBAE1,Agmo,HBB-BH1,CYP21A2,PHF8,CYP1A1,OGFOD3,LTF,NOS2,CYP2A12 |
| leukotriene-B4 20-monooxygenase activity | CYP4F18,CYP4F14,CYP4F12,CYP4A10,CYP4F3,CYP4F2 |
| arachidonic acid epoxygenase activity | CYP2A13,CYP2C54,CYP2B19,CYP2C9,CYP2AD3,CYP2C37,CYP2D6,CYP2P9,CYP2F2,CYP2J2 |
| alkane 1-monooxygenase activity | CYP4A14,CYP4A10,CYP4F2,CYP4F12,CYP4F18,CYP4A12A |
| heme binding | PTGS2B,CYP2K17,CYP2J6,JAK2,PTGS2,CYP4F2,CYP2V1,CBS,CYP1C1,CYP4Z1 |
Interacting Protein
CYP4A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4A11.
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References
- Chen, L; Ackerman, R; et al. 20-HETE Regulates the Angiogenic Functions of Human Endothelial Progenitor Cells and Contributes to Angiogenesis In Vivo. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 348:442-451(2014).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
