CYP2R1
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Official Full Name
cytochrome P450, family 2, subfamily R, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. -
Synonyms
CYP2R1;cytochrome P450, family 2, subfamily R, polypeptide 1;vitamin D 25-hydroxylase;Cytochrome P450 2R1;Cytochrome P450 family 2 R1;Cytochrome P450 family 2 subfamily R polypeptide 1;EC 1.14.13.15;MGC4663;Vitamin D 25 hydroxylase;OTTHUMP00000231476;cytochrome P450, family 2, R1
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2R1-1156R | Recombinant Rhesus monkey CYP2R1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CYP2R1-2269H | Recombinant Human CYP2R1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP2R1-7109HCL | Recombinant Human CYP2R1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP2R1-2123H | Recombinant Human CYP2R1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CYP2R1-2393HF | Recombinant Full Length Human CYP2R1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 501 amino acids |
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| Cyp2r1-2418M | Recombinant Mouse Cyp2r1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CYP2R1-981R | Recombinant Rhesus Macaque CYP2R1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CYP2R1-981R-B | Recombinant Rhesus Macaque CYP2R1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of steroid hormones and vitamin D | HSD17B11,GC,CYP27B1,AKR1B15,PPP1R2,CYP24A1,STARD5 |
| Phase 1 - Functionalization of compounds | CYP3C1,CYP2K16,CYP4T8,CYP2K18,CYP2K6,CYP2K19,CYP2Y3,CYP2V1,CYP27B1,CYP2U1 |
| Steroid biosynthesis | SQLEA,LIPA,SC4MOL,Cel,FDFT1,SC5D,SOAT2,HSD17B7,LSS,DHCR24 |
| Biological oxidations | GSTK1,CYP2K19,CYP3A7,CYP51A1,CYP17A1,FDX1,CYP27A1,CYP2S1,CYP2F1,ADH5 |
| Cytochrome P450 - arranged by substrate type | CYP2AD3,CYP2K8,FDXR,CYP2N13,CYP3C4,CYP2A13,CYP3A5,CYP4F11,CYP21A2,CYP2S1 |
| Metabolism | AWAT1,NUDT15,ZDHHC21,CYP2B6,ACOT6,SLC5A2,FTCD,MTF1,SLC25A15B,CYP4F11 |
| Metabolism of lipids and lipoproteins | ACOT8,ARSD,DECR1,GDF1,GPAT2,APOC2,TPTE,FA2H,PEMT,MED21 |
| Metabolic pathways | CCBL1,ACLYA,UQCRQ,POLR2K,EXTL3,SI,H6PD,ACO1,IDH2,HSD17B6 |
Protein Function
CYP2R1 has several biochemical functions, for example, heme binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid hydroxylase activity | CYP2C54,CYP2P8,CYP2J5,CYP2AA4,CYP2A7,CYP2X10.2,CH25H,CYP3A4,CYP2C19,CYP2X7 |
| iron ion binding | TMLHE,CYP2K19,CYP2AA8,CYP46A1.1,HBAE3,P4HA2,CYGB1,CYP2C37,CYP4F11,FDX1 |
| oxygen binding | CYP2C38,HBBE3,TH,CYP2X7,CYP2U1,CYGB1,HBE1,NGB,CYP1A4,HBAE1 |
| vitamin D3 25-hydroxylase activity | CYP3A4,FAM84B,CYP27A1 |
| heme binding | PTGS2,CYP2P8,CYP19A1B,GUCY1A3,FAM84B,CYP27B1,HBA2,CYP3A5,CYP2D10,CYP11B2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2AA12,CYP1A2,CYP2P9,CYP2AA4,CYP2J6,CYP2E1,CYP2J5,CYP2A12,CYP2AA6,CYP2AA8 |
Interacting Protein
CYP2R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2R1.
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