CYP2C8
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Official Full Name
cytochrome P450, family 2, subfamily C, polypeptide 8 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. -
Synonyms
CYP2C8;cytochrome P450, family 2, subfamily C, polypeptide 8;cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8;cytochrome P450 2C8;CPC8;CYPIIC8;Cytochrome P450 family 2 subfamily C polypeptide 8;Cytochrome P450 form 1;Cytochrome P450 IIC2;Cytochrome P450 MP-12;Cytochrome P450 MP-20;Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8;Flavoprotein linked monooxygenase;Microsomal monooxygenase;MP 12/MP 20;P450 form 1;P450 IIC2;P450 MP 12/MP 20;S mephenytoin 4 hydroxylase;Xenobiotic monooxygenase;s-mephenytoin 4-hydroxylase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8;MP-12/MP-20
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2C8-11773H | Recombinant Human CYP2C8, His-tagged | E.coli | Human | His | 142-490a.a. | |
| CYP2C8-1150R | Recombinant Rhesus monkey CYP2C8 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CYP2C8-120H | Recombinant Human CYP2C8, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 490 a.a. |
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| CYP2C8-384H | Recombinant Human CYP2C8 | Insect Cell | Human | Non |
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| CYP2C8-7114HCL | Recombinant Human CYP2C8 293 Cell Lysate | HEK293 | Human | Non |
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| CYP2C8-109HF | Recombinant Full Length Human CYP2C8 Protein | In Vitro Cell Free System | Human | GST | Full L. 1 a.a. - 490 a.a. |
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| CYP2C8-124C | Active Recombinant Cynomolgus CYP2C8 Protein | E.coli | Cynomolgus |
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| CYP2C8-14H | Active Recombinant Human CYP2C8 Protein | E.coli | Human |
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| CYP2C8-2794H | Recombinant Human CYP2C8 protein, His&Myc-tagged | E.coli | Human | His&Myc | 27-490aa |
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| CYP2C8-76H | Active Recombinant Human CYP2C8 Protein | E.coli | Human |
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| CYP2C8-975R | Recombinant Rhesus Macaque CYP2C8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CYP2C8-975R-B | Recombinant Rhesus Macaque CYP2C8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Kit-0895 | CYP2C8 Green Screening Kit | Non |
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Involved Pathway
CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | CYP2C70,AKR1C2,ARNT,ALDH3A1,UGT1A6A,GSTT2,CYP2C19,GSTM7,HSD11B1,CCBL1 |
| CYP2E1 reactions | CYP2A13,CYP2B6,CYP2E1,CYP2Y3,CYP2S1,CYP2C9,CYP2A7,CYP2C19,CYP2F1,CYP2A6 |
| Metabolic pathways | PC,ALDOAA,B3GNT4,MOCS1,SDS,P4HA1A,UPP2,AK4,HSD3B7,UGP2 |
| Drug metabolism - cytochrome P450 | CYP2C9,GSTK1,CYP3A5,ADH2-1,ADH2-2,ADH5,ADH6,GSTO2,ADH7,ADH1C |
| Linoleic acid metabolism | CYP2C9,PLA2G10,PLB1,PLA2G4AA,PLA2G3,ALOX15,CYP3A41B,PLA2G4F,PLA2G2A,PLA2G12A |
| Arachidonic acid metabolism | PTGES3B,PLA2G3,CYP4A11,PLA2G2F,GPX7,PTGDSA,CYP2C38,GPX6,CYP2P7,EPHX2 |
| Cytochrome P450 - arranged by substrate type | CYP46A1,CYP51A1,CYP4F22,CYP2F1,CYP2U1,CYP2D6,CYP1B1,CYP2Y3,FDX1,CYP2AD2 |
| Biological oxidations | ACY3,ADH4,NCOA2,ADH1B,CYP2A6,SULT1ST6,CYP2B6,CYP4T8,MTRR,SULT2ST1 |
Protein Function
CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity,(S)-limonene 6-monooxygenase activity,(S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP4A10,CYP4F12,CYP4F14,CYP51A1,HBBE3,CYP4Z1,HBB-Y,XGB,TDO2B,CYP2A12 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2A6,CYP2A13,CYP1A,CYP2AA9,CYP2X9,CYP2Y3,CYP2AD6,CYP2X8,CYP2D10,CYP2A4 |
| monooxygenase activity | CYP2D26,CYP2AA8,CYP2D6,CYP2AA3,CYP26C1,CYP2AA2,CYP2P10,YWHAE1,COQ6,CYP3A4 |
| oxygen binding | CYP2C50,CYP3A5,CYP2P6,CYP2AA9,CYP2Y3,CYP2X10.2,CYP2AA3,CYP2C18,XGB,HBA1 |
| (R)-limonene 6-monooxygenase activity | CYP2C9,CYP2C19 |
| (S)-limonene 6-monooxygenase activity | CYP2C19,CYP2C9 |
| (S)-limonene 7-monooxygenase activity | CYP2C9,CYP2C19 |
| iron ion binding | ALOX15,CYP20A1,ALOX5B.2,CYP2C38,CYP2AA6,CYP2V1,EGLN1,CYP2C39,CYP1A1,HBAA |
| enzyme binding | NOXA1,CYP1A2,CREB1,CD40,KAT8,ATF7,MAPK8,UBE2I,UGT1A2,EGFR |
Interacting Protein
CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.
PGRMC1;A2M;APOE;DNAJB1;LONP1;BLMH;RIN3;MAST1;GABARAPL1;MAP1LC3A
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References
- Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
- Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).
