CYP20A1
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Official Full Name
cytochrome P450, family 20, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. -
Synonyms
CYP20A1;cytochrome P450, family 20, subfamily A, polypeptide 1;cytochrome P450 20A1;CYP M;CP20A_HUMAN;Cytochrome P450 monooxygenase;MGC22229;CYP-M
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP20A1-11767H | Recombinant Human CYP20A1, His-tagged | E.coli | Human | His | 112-462a.a. | |
| CYP20A1-2825H | Recombinant Human CYP20A1 protein, His-tagged | E.coli | Human | His | 112-248 aa | |
| CYP20A1-12517Z | Recombinant Zebrafish CYP20A1 | Mammalian Cell | Zebrafish | His |
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| CYP20A1-1718R | Recombinant Rat CYP20A1 Protein | Mammalian Cell | Rat | His |
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| CYP20A1-2248H | Recombinant Human CYP20A1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP20A1-4151M | Recombinant Mouse CYP20A1 Protein | Mammalian Cell | Mouse | His |
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| CYP20A1-7124HCL | Recombinant Human CYP20A1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP20A1-1377R | Recombinant Rat CYP20A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CYP20A1-1377R-B | Recombinant Rat CYP20A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CYP20A1-2128M | Recombinant Mouse CYP20A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CYP20A1-2128M-B | Recombinant Mouse CYP20A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CYP20A1-2305HF | Recombinant Full Length Human CYP20A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 462 amino acids |
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Involved Pathway
CYP20A1 involved in several pathways and played different roles in them. We selected most pathways CYP20A1 participated on our site, such as cytochrome P450,metapathway biotransformation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP20A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cytochrome P450 | CYP2W1,POR,CYP4V2,CYB5A,CYP4Z1,CYP2A7,CYB5R3,CYB5B,CYP4F12 |
| metapathway biotransformation | RHBDL1,CYP2W1,SULT1C4,SULT1B1,HS3ST4,NAA50,NAT14,NAA40,KCNAB2,CEACAM21 |
Protein Function
CYP20A1 has several biochemical functions, for example, heme binding,iron ion binding,monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP20A1 itself. We selected most functions CYP20A1 had, and list some proteins which have the same functions with CYP20A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monooxygenase activity | CYP2AA12,CYP2J6,CH25HL2,CYP2B19,CYP17A2,CYP1D1,CYP1A4,CYP3A4,CYP4A14,CYP2K22 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP27C1,CYP51,CYP8B3,CYP2P10,P4HA1B,CYP3C1,CYP21A1,EGLN1B,CYP2C39,CYP1A |
| iron ion binding | CYP2X10.2,HBBE3,P3H2,CYGB2,FDX1,CYP19A1,CYP2A13,CYP3C4,CYP1A2,KDM3A |
| heme binding | CYP2J6,CYP3C1L2,CYP1C2,CYP7B1,TPO,HBD,CYP2A4,CYP1D1,HBB-B2,CYP17A2 |
Interacting Protein
CYP20A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP20A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP20A1.
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References
- Nyante, SJ; Gammon, MD; et al. Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects. CANCER CAUSES & CONTROL 26:121-131(2015).
- Zou, JG; Ma, YT; et al. The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China. LIPIDS IN HEALTH AND DISEASE 13:-(2014).
