CXCR4
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Official Full Name
chemokine (C-X-C motif) receptor 4 -
Overview
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
CXCR4;chemokine (C-X-C motif) receptor 4;FB22;HM89;LAP3;LCR1;NPYR;WHIM;CD184;LAP-3;LESTR;NPY3R;NPYRL;HSY3RR;NPYY3R;D2S201E;C-X-C chemokine receptor type 4;fusin;CD184 antigen;SDF-1 receptor;LPS-associated protein 3;neuropeptide Y receptor Y3;seven transmembrane helix receptor;stromal cell-derived factor 1 receptor;lipopolysaccharide-associated protein 3;seven-transmembrane-segment receptor, spleen;leukocyte-derived seven transmembrane domain receptor
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- Saimiri sciureus (Common squirrel monkey)
- Felis catus
- Papio anubis (Olive baboon)
- Pan troglodytes
- Macaca mulatta
- Sheep
- Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
- Macaca fascicularis
- Chlorocebus Aethiops
- Tupaia chinensis (Chinese tree shrew)
- Dog
- Sus scrofa (Pig)
- Mus musculus
- Bovine
- Callithrix jacchus (White-tufted-ear marmoset)
- Rat
- Wheat Germ
- Human Cells
- HEK293
- Mammalian Cells
- E.coli
- Yeast
- In Vitro Cell Free System
- Non
- His
- His&Myc&SUMO
- Fc
- GST
- His&Flag
- His&Fc&Avi
- His&SUMO
- His&GST
Involved Pathway
CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Intestinal i | HLA-DPA1,HLA-DOB,LTBR,IL5,MADCAM1,HLA-DOA,HLA-DPB1,H2-AB1,HLA-DRB3,CD86 |
| ne network for IgA production | BLB2,HLA-DRB5,Icosl,CCL25B,CCL28,TNFRSF13B,HLA-DPB1,IL15RA,MAP3K14,HLA-DRA |
| Endocytosis | ARPC4L,WASLB,ARRB2B,KIT,GRK1,ADRB2B,FOLR3,CDC42,IGF1RA,CAPZA3 |
| Chemokine signaling pathway | CXCL3,CCL18,CXCL10,CXCL5,ADRBK1,GM1987,CCL14,KRAS,PREX1,CCL25 |
| Leukocyte transendothelial migration | CLDN22,PIK3R3,MYL10,PTK2,NIPAL1,PTPN11,CYBB,CYBA,VAV3,ACTN3 |
| Axon guidance | DPYSL5,FGF10B,CSNK2A1,PPP3CB,LAMTOR2,PPP3CA,DUSP4,TRPC3,NRP2,AGRN |
| Cytokine-cytokine receptor interaction | Kitl,CCL1,FLT3,FASLG,LEPB,CSF1RA,IFNA4,TGFB1,EDAR,PDGFRA |
| Pathways in cancer | FZD8,BDKRB1,WNT10B,RAC1,RAF1,ARHGEF12,FGF17,FGF4,CTBP2,LAMA4 |
Protein Function
CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity,G-protein coupled receptor activity,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KIAA1530,BIRC2,SEMA3E,CLUAP1,RNF146,RARRES3,PLEK,MYO1E,DEPDC1,RBBP8 |
| coreceptor activity | RAMP2,CCR5,ACVR2A,ACKR3B,LY96,CD8B,CD8A,TMIGD2,CD86,CXCR7B |
| G-protein coupled receptor activity | SETD6,S1PR5B,LPAR5A,OR10A4,OPN4XB,GRM2,ADRA2DA,TAAR12F,NPFFR1L1,OLFR154 |
| ubiquitin binding | UBAP1,TNFAIP3,RNF168,FAF1,PER2,USP16,UBXN2B,BCL10,UBR5,SHRPRBCK1R |
| actin binding | PHACTR3B,MYH8,EZR,INPPL1B,WASF1,INPPL1,TMOD3,DNASE1,FMNL2,RP2 |
| myosin light chain binding | MYOC,SPATA6,MYO19 |
| virus receptor activity | HYAL2,TNFRSF4,SLC52A2,DAG1,CD209A,CD86,CR1,XPR1,GPR172B,LDLR |
| cytokine binding | CSF1R,IL31RA,NRP2,IL17F,CNTFR,CSF1RA,Fzd4,CRLF1,CHRD,NOG |
| C-X-C chemokine receptor activity | CXCR2,CXCR3.1,CCBP2,CXCR7,CCR9A,CXCR4A,CXCR5,CXCR6,CXCR3,CXCR4B |
Interacting Protein
CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.
DBN1;CD74;MYH9;Dbn1;CD164;CCR5
CXCR4 Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsNeuroinflammation
Immune Regulatory Molecules on Endothelial Cells
Cytokine and Growth Factor Receptors on VSMC
Somite Markers
Endothelial Cell Differentiation Markers
Chemokine Receptors
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Hematopoietic Stem Cell Markers
Neural Stem Cell Markers
B Cell Chemotaxis, Migration, and Adhesion
gamma delta T Cells
Regulatory T Cells (Tregs)
T Cell Migration
Megakaryocytes
Monocyte Markers
Breast Cancer Stem Cell Markers
Glioma/Medulloblastoma Cancer Stem Cell Markers
Pancreatic Cancer Stem Cell Markers
Endodermal Lineage Markers
T Follicular Helper (Tfh) Cells
Th2 Cells
CXC Chemokine Receptors
Melanoma Biomarkers
Related Services
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References
- Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
- Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).
