CTSL2

  • Official Full Name

    Cathepsin L2

  • Overview

    Cathepsin V, also known as Cathepsin L2, is a 334 amino acid protein that belongs to the peptidase C1 family and is found in the lysosome. It is a Cysteine protease that may have an important role in corneal physiology. It can also function as a hydrolase and thiol protease. The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Cathepsin V is expressed predominantly in the thymus and testis. It is also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.

  • Synonyms

    UNQ268/PRO305;CATL2;CTSU;CTSV;cathepsin L2, preproprotein;cathepsin U;cathepsin V

Recombinant Proteins

  • Human
  • Chicken
  • Human Cell
  • Mammalian Cell
  • Free Style 293-F Cell
  • Insect Cell
  • Mammalian cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CTSL2-614H Recombinant Human CTSL2, His tagged Human Cell Human His Full L. 1-334 a.a.
CTSL2-4041C Recombinant Chicken CTSL2 Mammalian Cell Chicken His
CTSL2-507H Recombinant Human Cathepsin L2, His-tagged Free Style 293-F Cell Human His 1-16;18-334 a.a.
CTSL2-681H Recombinant Human Cathepsin L2, His-tagged Insect Cell Human His
CTSL2-751H Recombinant Human Cathepsin L2, His-tagged Mammalian cells Human His 18-334 a.a.
CTSL2-7191HCL Recombinant Human CTSL2 293 Cell Lysate HEK293 Human Non
CTSL2-2755H Recombinant Human CTSL2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CTSL2-2755H-B Recombinant Human CTSL2 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    CTSL2 involved in several pathways and played different roles in them. We selected most pathways CTSL2 participated on our site, such as Activation of Matrix Metalloproteinases,Adaptive Immune System,Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen formation COL6A2,COL17A1A,COL5A3B,CTSL1,ABHD1,COL17A1,CRTAP,MMP20,LEPRE1,ADAMTS3
    Class I MHC mediated antigen processing &amp LRSAM1,FBXO27,RNF41,UBE2U,UFL1,TRIM9,SEC61B,KLHL20,PJA2,KLHL21
    presentation ASB11,TPP2,UBR1,ASB18,TRIM69,BLMH,DTX3L,RNF34,RNF41,SEC61B
    Degradation of the extracellular matrix COL15A1B,CTSL1,ADAMTS8,BSG,CMA1,MMP24,MMP12,COL19A1,ADAM9,CTSD
    Activation of Matrix Metalloproteinases MMP15,MMP8,CTRB1,MMP11,LOC100686744,MMP24,CTSG,MMP10,MMP17,MGC174155
    Assembly of collagen fibrils and other multimeric structures COL6A2,COL6A1,COL1A2,COL5A3A,COL2A1,COL8A2,MMP13,LOX,COL8A1,LOXL1
    Adaptive Immune System NA,RNF182,ITK,AP1G1,SH2D1B,FRS2B,KIF3B,CD300LH,SIGLEC12,RNF6
    Endochondral Ossification NKX3-2,PTH,PTHLH,KIF3A,CST5,FRZB,COL10A1,RUNX3,DDR2,COL10A1A
    Antigen processing-Cross presentation FCGR1B,CYBA,CD207,CTSS,SEC61B,CTSL1,CYBB

    Protein Function

    CTSL2 has several biochemical functions, for example, aminopeptidase activity,cysteine-type carboxypeptidase activity,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL2 itself. We selected most functions CTSL2 had, and list some proteins which have the same functions with CTSL2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PSMD6,IMP3,RBM4,CCR3,TMEM171,GREM1,CUL9,RRAGA,ABHD14B,CDPF1
    aminopeptidase activity ERAP1,METAP1D,XPNPEP2,XPNPEP3,Ctsl,NPEPPS,TRHDE,XPNPEP1,METAP2B,PEPD
    cysteine-type peptidase activity CTSW,CASPB,ATG4A,CTSH,SENP8,CTSBB,CASPC,CASP8,OTUD6B,PSD
    kininogen binding C1QBP,CTSB,Ctsl
    peptide binding GNRHR1,AVPR2L,PCSK5,OXTRL,CALR,GPR37L1,TPP1,MAS1,GNRHR,PLOD1
    cysteine-type carboxypeptidase activity Ctsl
    cysteine-type endopeptidase activity CTSS,ATG4B,USP51,USP45,USP9,CASPA,USP28,CTSC,USP5,USP6
    histone binding CHAF1B,PIH1D1,ASF1A,HIST1H4C,DNAJC2,HINFP,HIST1H3C,TBL1XR1,CHD2,TONSL
    protein complex binding AP2A2,BAG3,PEX1,FBN1,GNB2,MTAP1B,TUBB,CASP8,PDZK1,CAPG

    Interacting Protein

    CTSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL2.

    srp-6;BUB1;RB1;SRC;BRAF;APC;CTNNA1;BMPR1A;MLH1;DCC;PDGFRL;CDKN2A;DLC1;MLH3

    Resources

    Research Area

    Lysosomal Enzymes

    References

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