CTSL1
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Official Full Name
cathepsin L1 -
Overview
Cathepsin L is a lysosomal endopeptidase belonging to the papain cysteine protease superfamily. Macrophages and osteoclasts secrete the precursor of cathepsin L, procathepsin L, which is processed to some form of active enzyme by acid, surface activation, or proteolysis. It is then involved in connective tissue degradation and the turnover of extracellular matrix proteins. Procathepsin L is also secreted by many malignantly transformed cells, mRNA, and its protein expression levels, as well as the extent to which it is secreted are correlated to the malignant potential of these cells. As cathepsin L is capable of degrading protein constituents of the extracellular matrix, it may play a crucial role in tumor progression, metastasis, and other disorders involving the destruction of the extracellular matrix. Inhibition of the enzyme or the proenzyme by low molecular weight inhibitors or antibodies and in vivo lead to a suppression of the invasiveness of malignant cells or a decline in their ability to form tumors. -
Synonyms
RP11-65B23.1;CATL;CTSL;MEP;cathepsin L;major excreted protein
Recombinant Proteins
- Human
- Rat
- Chlorocebus Aethiops
- E.coli
- HEK293
- Mammalian Cell
- Human Cell
- Human Liver
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CTSL1-11690H | Recombinant Human CTSL1, GST-tagged | E.coli | Human | GST | 1-333a.a. | |
| CTSL1-896H | Recombinant Human CTSL1 protein(Thr 18 - Val 333) | HEK293 | Human | His | Thr 18 - Val 333 | |
| CTSL1-1668R | Recombinant Rat CTSL1 Protein | Mammalian Cell | Rat | His |
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| CTSL1-26491TH | Recombinant Human CTSL1, His-tagged | E.coli | Human | His | Full L. |
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| CTSL1-91H | Recombinant Human cathepsin L1 | E.coli | Human | Non | 1-87 a.a. |
|
| CTSL1-3022HCL | Recombinant Human CTSL1 cell lysate | Human Cell | Human | Non |
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| CTSL1-1327R | Recombinant Rat CTSL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CTSL1-1327R-B | Recombinant Rat CTSL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CTSL1-1859H | Native Human Cathepsin L1 | Human Liver | Human | Non |
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| CTSL1-27406TH | Native Human CTSL1 | Human | Non | Full L. |
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| CTSL1-441C | Recombinant Chlorocebus Aethiops CTSG Protein (114-333 aa), His-SUMO-tagged | E.coli | Chlorocebus Aethiops | His&SUMO | 114-333 aa |
|
Involved Pathway
CTSL1 involved in several pathways and played different roles in them. We selected most pathways CTSL1 participated on our site, such as Adaptive Immune System,Antigen processing and presentation,Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing-Cross presentation | CYBB,CD207,FCGR1B,CTSS,SEC61B,CTSL2,CYBA |
| Assembly of collagen fibrils and other multimeric structures | COL8A1,BMP1B,COL6A2,COL4A3,LOXL3,PCOLCE,DST,CTSL2,MMP20,COL5A3B |
| presentation | RNF123,RNF138,ASB17,LRR1,TRIM63,RNF14,FBXO44,B2ML,FBXO3,SEC61B |
| Adaptive Immune System | CTSL2,CTSO,CREB1,DCTN3,MICA,AP2A2,RNF138,CD300LB,AP1M2,SPSB4 |
| Degradation of the extracellular matrix | CTSS,MMP20,COL25A1,ADAMTS4,NID1,CTSK,COL9A3,TIMP2,CTS7,ACAN |
| Antigen processing and presentation | HLA-DMB,KIR2DS5,HSPA5,HLA-DRB3,CD8A,CTSS,HSPA1L,PSME2,HLA-E,HSPA2 |
| Class I MHC mediated antigen processing & | PJA2,ASB8,CMTM2A,BLMH,ERAP1,RNF25,SPSB1,ASB11,SPSB4,RNF220 |
| Collagen formation | COL5A1,MMP20,CTSB,LOXL4,SERPINH1,COL13A1,COL2A1,CTSL2,COL4A4,LOXL1 |
| Collagen degradation | CTSD,MMP19,MMP10,COL25A1,ADAM9,COL15A1B,MMP13,ELANE,MMP12,COL9A3 |
Protein Function
CTSL1 has several biochemical functions, for example, collagen binding,cysteine-type endopeptidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL1 itself. We selected most functions CTSL1 had, and list some proteins which have the same functions with CTSL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibronectin binding | CCDC80,MFAP2,MYOC,PLEKHA2,IGFBP3,ITGB3,ITGB1A,IGFBP5,ITGB1,LPA |
| collagen binding | LUM,C1QTNF1,COMP,ITGA1,HSD17B12,DCN,VWF,CTSB,SPARC,SMAD7 |
| histone binding | H3F3B,LEF1,UHRF2,HIST2H4A,RNF20,BAZ2A,NCAPD3,PRKCBP1L,HIST1H3G,USP3 |
| protein binding | PDK3,WWP2,LSM8,TRIM59,KRT80,EDAR,NARG1,HMGB3,CAP2,IPO7 |
| cysteine-type peptidase activity | DUB1,OTUD4,CAPN3A,PGPEP1,SENP3B,CASPB,GM12824,CTSM,CAPN3,PSD |
| proteoglycan binding | FCN2,CTSS,NID1,CECR1A,UBE4A,THBS1,CTSK,SLIT2,CTSB,CECR1 |
| cysteine-type endopeptidase activity | USP18,CTS7,CTSF,ATG4D,MALT1A,CTSM,FAM49BA,CASP14,CTLA2B,USP44 |
Interacting Protein
CTSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL1.
SGTA;srp-6;BTN3A3;EED;PPP1CC;GEM;RELB;CRELD2;alsS;IGHA1;APOA1;ALB;TF;cona_canen
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References
- Mas-Coma, S; Bargues, MD; et al. Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. PARASITOLOGY 141:1918-1946(2014).
- Toet, H; Piedrafita, DM; et al. Liver fluke vaccines in ruminants: strategies, progress and future opportunities. INTERNATIONAL JOURNAL FOR PARASITOLOGY 44:915-927(2014).
