CTRC
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Official Full Name
Chymotrypsin C (Caldecrin) -
Overview
Chymotrypsin is a digestive enzyme that can perform proteolysis. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a tyrosine, tryptophan, or phenylalanine. These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. The hydrophobic and shape complementarity between the peptide substrate P1 sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine at the P1 position -
Synonyms
CTRC;chymotrypsin C (caldecrin);elastase IV;CLCR;serum calcium decreasing factor;ELA4;Caldecrin;EC 3.4.21.2;chymotrypsin-C;EC 3.4.21;elastase 4;OTTHUMP00000002321
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Bovine
- Neisseria meningitidis serogroup A / serotype 4A
- Neisseria Meningitidis Serogroup B
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Human Cell
- Bovine Pancreas
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
CTRC involved in several pathways and played different roles in them. We selected most pathways CTRC participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism,Metabolism,Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | GLTP,NDOR1,CETP,FAAH2,CYP4B1,GGTLC1,DUT,OAZ3,INSIG2,ETFB |
| Metabolism of vitamins and cofactors | NAMPT,SLC23A2,CBLC-1,SLC25A32,CYB5A,ELA2L,GPHNA,KCNG4,MMADHC,SLC5A6B |
| Metabolism of water-soluble vitamins and cofactors | MOCOS,CTRB1,TCN1,SLC52A3,ELA2L,SLC5A6B,SLC25A32A,CBLC-1,KCNG4,GPHNA |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | AMN,ELA2,CD320,MTRR,LOC100686744,CBLC-1,MMAA,MMADHC,ELA2L,TCN1 |
Protein Function
CTRC has several biochemical functions, for example, peptidase activity,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTRC itself. We selected most functions CTRC had, and list some proteins which have the same functions with CTRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PCSK5,PRSS33,PRSS3,F9A,KLK5,FAP,FURIN,KLK10,TPP2,TMPRSS3 |
| peptidase activity | FAM49BA,MCPT8,USP43,KLK1B11,CLPP,TMPRSS13A,BMP1A,CPD,CTSJ,ZMPSTE24 |
| protein binding | MAB21L2,LRDD,F3,GLS2,LIN9,HSPA6,NOX5,CCDC25,TM4SF4,C16orf70 |
Interacting Protein
CTRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTRC here. Most of them are supplied by our site. Hope this information will be useful for your research of CTRC.
KRTAP10-7
Resources
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References
- Lacruz, RS; Smith, CE; et al. Chymotrypsin C (Caldecrin) Is Associated with Enamel Development. JOURNAL OF DENTAL RESEARCH 90:1228-1233(2011).
- Wang, HB; Yuan, DD; et al. Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 43:568-575(2011).
