CTNNA1
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Official Full Name
catenin (cadherin-associated protein), alpha 1, 102kDa -
Overview
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR. -
Synonyms
alpha catenin;alpha E catenin;alphaE catenin;Cadherin associated protein 102kDa;Cadherin associated protein;CAP 102;CAP102;Catenin (cadherin associated protein) alpha 1 102kDa;Catenin (cadherin associated protein), alpha 1, 102kDa;Catenin alpha 1;CTNNA 1;CTNNA1;FLJ36832;FLJ52416;NY REN 13 antigen;OTHUMP00000224141;OTTHUMP00000224147;Renal carcinoma antigen NY REN 13 alpha catenin;Renal carcinoma antigen NY REN 13;alpha-Cat;a-cat;alpha-ctn;alphacat;CG17947;CT39986;Dalpha-cat;Dalpha-catenin;DalphaC;Dalphacat;Dmcatp;Dmel\CG17947;CG17947-PA;D-alpha-catenin;Dalpha-cadherin;DalphaCatenin;a-catenin;alpha-Cat-PA;alpha-Catenin;alphaCatenin;CG17947 gene product from transcript CG17947-RA
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
CTNNA1 involved in several pathways and played different roles in them. We selected most pathways CTNNA1 participated on our site, such as Adherens junction,Adherens junctions interactions,Arf6 trafficking events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bacterial invasion of epithelial cells | CDC42,VCL,SEPT2,CBLC,ARPC4,SEPT6,PIK3R1,SHC1,SEPT1,CBLB |
| Arf6 trafficking events | SCAMP2,EDNRB,SPAG9,ADRB2,EXOC3,DNM2,EXOC5,CTNND1,CPE,EXOC6 |
| Adherens junction | RAC1,RAC1B,CDC42,PVRL4,RHOAA,ACP1,PTPRJ,ACTB1,TCF7L1A,ACTB2 |
| CDC42 signaling events | ARPC3,EPS8,TNK2,ARPC2,ARPC5,ACTR2,ACTR3,CFL1,ARPC4,PAK4 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA6,ITGA9,CACNG1,ITGB5,SLC8A1,CACNG8,ACTN2,ACTN1,CACNA2D3,CACNB1 |
| Adherens junctions interactions | CDH11,CDH18A,JUP,CTNNB1,CDH6,CDH7,CDH4,CDH18,PTBP3,CDH12 |
| Arrhythmogenic right ventricular cardiomyopathy | DSC2,DMD,CTNNA2,JUP,CDH2,CACNG2,DSG2,DSP,DAG1,CACNG3 |
| CDO in myogenesis | BNIP2,MYOG,CTNNA2,TCF4,TCF3B,CDH2,CDON,CDH4,TCF12,MEF2AA |
Protein Function
CTNNA1 has several biochemical functions, for example, actin filament binding,beta-catenin binding,cadherin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNA1 itself. We selected most functions CTNNA1 had, and list some proteins which have the same functions with CTNNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cadherin binding | NEO1,TBC1D2,TRPC4,PROM1,VCL,CD2AP,NDRG1,CDH13,MMP24,CTNNA3 |
| protein binding | CPNE1,BTN2A2,VAV2,AGBL4,TFG,CCNT1,THRAP3,GZMA,AP5S1,CSF3R |
| beta-catenin binding | NUMB,SMAD7,Ar,LZIC,SMAD3,CBY1,DACT2,PTBP3,LEF1,VCL |
| vinculin binding | SYNM,DMD,DAG1,SORBS3,ACTN1,NRAP,TLN1,PXN,C22orf28 |
| structural molecule activity | KRTAP11-1,CLDN7A,SPRR1B,CLDNJ,PRPH,SPRR2F,KRT28,CLDNB,FGG,TUBG2 |
| actin filament binding | MYH9A,TNNC1,MAP1S,TAGLN3A,SHROOM2,VCLA,CORO6,SYNE3,DBNLB,ADD1 |
| gamma-catenin binding | TCF7L2,APC,PTPRK,PTPRJ,Fert2,FER,LEF1,CDH1,PTBP3,APC2 |
| poly(A) RNA binding | MTERF,ZFP36,FAM50A,KIF1C,HIST1H4J,PDIA4,ANXA2,ZCCHC11,HIST1H4N,STRAP |
Interacting Protein
CTNNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNA1.
APC;EGFR;CDH1;JUP;ARRB2;CTNNB1;ACTN1;Ctnnb1;Cep350
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References
- Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
- Lee, B; Yoon, K; et al. Homozygous Deletions at 3p22, 5p14, 6q15, and 9p21 Result in Aberrant Expression of Tumor Suppressor Genes in Gastric Cancer. GENES CHROMOSOMES & CANCER 54:142-155(2015).
