CSTB
-
Official Full Name
cystatin B (stefin B) -
Overview
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). -
Synonyms
CSTB;cystatin B (stefin B);EPM1, STFB;cystatin-B;CST6;PME;CPI-B;liver thiol proteinase inhibitor;ULD;EPM1;STFB;EPM1A
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Chicken
- Cattle
- E.coli
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi&Fc&His
- DDK&Myc
- His&SUMO
Involved Pathway
CSTB involved in several pathways and played different roles in them. We selected most pathways CSTB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CSTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CSTB has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity,endopeptidase inhibitor activity,peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSTB itself. We selected most functions CSTB had, and list some proteins which have the same functions with CSTB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | MBNL2,PTPN1,UBE2L3,MAK16,ADARB2,PRPF40A,RBM4B,RPS10,OASL,KIF1C |
| peptidase inhibitor activity | A2ML1,KAL1A,SPINK8,SPINK6,SERPINA3K,PTTG1,WFDC15A,NGP,WFDC6B,WFDC6A |
| endopeptidase inhibitor activity | WFDC2,A2ML,AHSG,MUG2,SERPINA1E,MUG1,PSMF1,STFA2,A1i3,CAST |
| cysteine-type endopeptidase inhibitor activity | LCN1,CST7,NGP,CTLA2B,NAIP1,CST11,CARD17,PTTG1,WFDC2,STFA2 |
| protease binding | TRIP4,SRI,TNF,FAP,LCN2,Serpina1b,DERL1,RNF139,POLG,TIMP2A |
Interacting Protein
CSTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSTB here. Most of them are supplied by our site. Hope this information will be useful for your research of CSTB.
Ywhae;Ywhah;Hsd3b4;Pgls;Hsd3b7
Resources
Related Services
Related Products
References
