CST6
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Official Full Name
cystatin E/M -
Overview
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. -
Synonyms
CST6;cystatin E/M;cystatin-M;CST 6;Cystatin 6;Cystatin E;Cystatin M;Cystatin M/E;Cystatin-6;Cystatin-E;Cystatin6;CystatinE;CystatinM;Cysteine proteinase inhibitor;CYTM_HUMAN;OTTHUMP00000234150;ichq;N28197;1110017E11Rik
Recombinant Proteins
- Human
- Mouse
- Human Cell
- Human E.coli
- Mammalian cells
- HEK293
- Wheat Germ
- E.coli
- Human
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CST6 involved in several pathways and played different roles in them. We selected most pathways CST6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CST6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CST6 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST6 itself. We selected most functions CST6 had, and list some proteins which have the same functions with CST6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity | BIRC5B,CARD18,AHSG2,CST9,CST3,CST4,HRG,CST14B.1,NAIP1,CSTL1 |
Interacting Protein
CST6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST6.
BCAR3;TGFB1;GSK3B;NOTCH2;RAD51;PALB2
Resources
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References
