CSPG5
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Official Full Name
chondroitin sulfate proteoglycan 5 (neuroglycan C) -
Overview
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CSPG5;chondroitin sulfate proteoglycan 5 (neuroglycan C);chondroitin sulfate proteoglycan 5;NGC;Acidic leucine rich EGF like domain containing brain protein;Acidic leucine-rich EGF-like domain-containing brain protein;Caleb;CSPG5_HUMAN;MGC44034;Neuroglycan C;OTTHUMP00000164796;OTTHUMP00000164797;OTTHUMP00000210429
Recombinant Proteins
- Mouse
- Human
- Rat
- Cynomolgus
- Chicken
- CHO
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- His
- GST
- His&Fc&Avi
Involved Pathway
CSPG5 involved in several pathways and played different roles in them. We selected most pathways CSPG5 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,CS/DS degradation,Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSPG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| chondroitin sulfate biosynthesis | BGNA,B3GAT2,BCAN,CSPG4,DCN,BGN,NCAN,VCAN,VCANB,CHST9 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | CSPG4,GPC6,DCN,BCAN,AGRN,VCAN,GPC5,BGN,NCAN |
| CS/DS degradation | VCANB,DCN,NCAN,CSPG5B,BGNA,CSPG4,BGNB,VCAN,BGN,BCAN |
| Defective B4GALT7 causes EDS, progeroid type | GPC6,GPC5,DCN,AGRN,BCAN,BGN,NCAN,VCAN,CSPG4 |
| Defective B3GAT3 causes JDSSDHD | GPC6,GPC5,NCAN,AGRN,BGN,DCN,BCAN,VCAN,CSPG4 |
| Chondroitin sulfate/dermatan sulfate metabolism | BCAN,CSPG5B,BGNA,GPC1A,GPC1B,B3GAT2,Gpc2,B4GALT7,BGN,DSEL |
| A tetrasaccharide linker sequence is required for GAG synthesis | GPC1A,BGN,NCAN,AGRN,BGNA,CSPG4,GPC5A,GPC1B,BCAN,CSPG5B |
| Defective CHST14 causes EDS, musculocontractural type | BGN,BCAN,DCN,CSPG4 |
Protein Function
CSPG5 has several biochemical functions, for example, growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSPG5 itself. We selected most functions CSPG5 had, and list some proteins which have the same functions with CSPG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RSPH1,NFKB2,DMKN,MKRN2,DNASE1,FSD2,PTPN11,ZNF670,TBATA,QKI |
| growth factor activity | NRG1,GDNF,FGF6B,SPAW,TIMP1,CXCL12,TGFB1,OGN,FGF10B,NDR1 |
Interacting Protein
CSPG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSPG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSPG5.
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References
- Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
- Ho, LTY; Harris, AM; et al. A comparison of glycosaminoglycan distributions, keratan sulphate sulphation patterns and collagen fibril architecture from central to peripheral regions of the bovine cornea. MATRIX BIOLOGY 38:59-68(2014).
