CSNK1A1
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Official Full Name
casein kinase 1, alpha 1 -
Overview
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. -
Synonyms
CSNK1A1;casein kinase 1, alpha 1;casein kinase I isoform alpha;CK1;CK1a;CK1alpha;CKIa;CKIalpha;clock regulator kinase;CKI-alpha;down-regulated in lung cancer;HLCDGP1;PRO2975
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Chicken
- Pig
- Insect Cells
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- GST
- His
- His&GST
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
CSNK1A1 involved in several pathways and played different roles in them. We selected most pathways CSNK1A1 participated on our site, such as AMER1 mutants destabilize the destruction complex,APC truncation mutants have impaired AXIN binding,AXIN missense mutants destabilize the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSNK1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of SMO | KIF3A,EVC2,EVC,SETD6,ADRBK1,IQCE,GAS8,EFCAB7,BOC,CDON |
| Beta-catenin phosphorylation cascade | FAM123B |
| Canonical Wnt signaling pathway | DVL2,CSNK1D,DVL1,CSNK1E,DVL3,KLHL12 |
Protein Function
CSNK1A1 has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSNK1A1 itself. We selected most functions CSNK1A1 had, and list some proteins which have the same functions with CSNK1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTB1,KIF18B,PKN1B,NOD1,ENTPD3,GRK7,UBE2Q1,TRPV1,MAP3K9,CAMKK2 |
| protein kinase activity | SBK3,FYNB,KALRN,CLK2A,MAP3K11,CHEK1,DYRK3,SGK2B,CSNK1G2A,CDC7 |
| protein serine/threonine kinase activity | SLK,NEK7,CDK12,CAMK1DA,PRKACAB,MAPK14A,BMPR1B,MAP4K2,AKT2L,Aatk |
| protein binding | TNFRSF14,IKBKE,RPLP1,YBX1,CAPNS2,NPDC1,OTX1,SNRPF,HER11,IL23 |
Interacting Protein
CSNK1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSNK1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSNK1A1.
RIPK1;MDM4;q63629_rat;SEC16A;AXIN1;FAM83H;MDM2
Resources
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References
- Juhasz, K; Zvara, A; et al. Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells. IMMUNOLOGY LETTERS 152:55-64(2013).
- Chiarini, A; Armato, U; et al. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. PROTEOMICS 9:1850-1860(2009).
