CSHL1
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Official Full Name
chorionic somatomammotropin hormone-like 1 -
Overview
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CSHL1;chorionic somatomammotropin hormone-like 1;CSHP1;chorionic somatomammotropin CS 5;CS 5;CSL;hCS L;MGC149868;Chorionic somatomammotropin CS5;Chorionic somatomammotropin hormone like 1;Chorionic somatomammotropin like;CS5;Growth hormone cluster;hCSL;Lactogen like;chorionic somatomammotropin CS-5;CS-5;hCS-L
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CSHL1-11623H | Recombinant Human CSHL1, GST-tagged | E.coli | Human | GST | C-term-136a.a. | |
| CSHL1-7245HCL | Recombinant Human CSHL1 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
CSHL1 involved in several pathways and played different roles in them. We selected most pathways CSHL1 participated on our site, such as Cytokine Signaling in Immune system,Growth hormone receptor signaling,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | KDM4C,ARHGAP17A,TAS2R16,TAGAP,SKIB,ARHGAP29B,HCRT,PCSK5,PYGO1,FSTL1B |
| Nuclear signaling by ERBB4 | CSH1,CSN2,PRLRB,YAP1,WWOX,GHRB |
| Prolactin receptor signaling | PRLRB,GHRB,CSH1 |
| Cytokine Signaling in Immune system | EDARADD,PELI2,CASPB,DUSP2,PHB,IL1RN,FRS2A,IFIT11,ARIH1L,IRF9 |
| Growth hormone receptor signaling | CSH1,GHRB,CISH,PRLRB |
| Signaling by ERBB4 | PRLRB,WWOX,CSN2,GHRB |
| Immune System | DDX41,GBP5,ARIH1L,SRMS,KIF2A,IFIT2,FCGR1B,ASB3,GZMM,CTSB |
Protein Function
CSHL1 has several biochemical functions, for example, hormone activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSHL1 itself. We selected most functions CSHL1 had, and list some proteins which have the same functions with CSHL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | NAIP7,ZFP207,AMPD3,ZNF70,ASAP3,CYP2A12,Car4,TRMT44,ZFP239,FCNA |
| hormone activity | INS,IGF2,SST2,RLN2,CRHB,UTS2,CCK,AVP,LEP,PYY |
Interacting Protein
CSHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSHL1.
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