CSH1
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Official Full Name
chorionic somatomammotropin hormone 1 (placental lactogen) -
Overview
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. -
Synonyms
CSH1;chorionic somatomammotropin hormone 1 (placental lactogen);chorionic somatomammotropin hormone;choriomammotropin;chorionic somatomammotropin A;CSA;CSMT;FLJ75407;hCS A;PL;placental lactogen;CS-1;hCS-A
Recombinant Proteins
- Human
- Rhesus macaque
- Bovine
- S.cerevisiae
- HEK293
- Mammalian Cell
- E.coli
- Wheat Germ
- Human Cell
- Insect Cells
- Insect cells
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CSH1 involved in several pathways and played different roles in them. We selected most pathways CSH1 participated on our site, such as Cytokine Signaling in Immune system,Growth hormone receptor signaling,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | MARK3,GBP6,UBE2L6,EDARADD,NOD1,TRIM5,TNFRSF13C,NRG3,SPTB,EIF4E3 |
| Jak-STAT signaling pathway | SOCS3B,IL15RA,GRB2A,STAT3,IFNA6,IFNA17,STAT1A,IL7R,IL22RA2,SOCS6 |
| Prolactin receptor signaling | CSHL1,PRLRB,GHRB |
| Immune System | EDAR,TRIM38,CISH,KLRB1F,DEFA5,TRIM26,SIGLEC5,DEFB129,WWP1,DTX3L |
| Growth hormone receptor signaling | GHRB,PRLRB,CSHL1,CISH |
| PI3K-Akt signaling pathway | CDC37,EFNA4,CSH2,COMP,CSF1R,EFNA2,PRP2,LOC608458,EFNA3,PIK3AP1 |
| Nuclear signaling by ERBB4 | CSHL1,GHRB,PRLRB,CSN2,WWOX,YAP1 |
| Neuroactive ligand-receptor interaction | HTR5AL,PTGER2,CHRNA5,PRLR,TRPV1,F2RL2,NR3C1,NPFFR2,LHBETA1,TAAR4 |
Protein Function
CSH1 has several biochemical functions, for example, hormone activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSH1 itself. We selected most functions CSH1 had, and list some proteins which have the same functions with CSH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF684,DYRK4,NT5C2,PLAGX,EGLN1B,ZFP668,SNRNP48,AMHR2,TH2,ZNF773 |
| hormone activity | UTS2,LEPB,INSL5B,SST3,SMTLA,C19orf80,PRL7D1,CCL25,UCN3,APLN |
Interacting Protein
CSH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSH1.
SMAD9;PTPN12;SMAD4;SMAD2
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