CRYBA2
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Official Full Name
crystallin, beta A2 -
Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. -
Synonyms
CRYBA2;crystallin, beta A2;beta-crystallin A2;Beta A2 crystallin;Beta crystallin A2;eye lens structural protein
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRYBA2 involved in several pathways and played different roles in them. We selected most pathways CRYBA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRYBA2 has several biochemical functions, for example, molecular_function,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYBA2 itself. We selected most functions CRYBA2 had, and list some proteins which have the same functions with CRYBA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SLC26A5,ANO2,MID2,SRM,SMAGP,ODC1,CIDEA,ASCL1,CSF1R,TERF1 |
| protein binding | PHYHD1,SCEL,GTF2H2C_2,KLF5,MAGEB2,MAGED1,PTK2,DDX42,CDK16,HSPD1 |
| molecular_function | DIP2B,IER3IP1,TMEM106BB,METTL23,ARHGEF37,EML5,GTSE1,D4BWG0951E,RSPH3B,ZSWIM7 |
| structural constituent of eye lens | CRYGN2,CRYGC,LIM2.1,LIM2.4,ATXN1,CRYBA1,CRYABB,CRYGA,MIP,BFSP2 |
Interacting Protein
CRYBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYBA2.
PIK3R3;TRIP13;CRYBB3;CRYBB2;CRYBB1;CALCOCO1
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