CROT
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Official Full Name
carnitine O-octanoyltransferase -
Overview
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described. -
Synonyms
CROT;carnitine O-octanoyltransferase;peroxisomal carnitine O-octanoyltransferase;COT;Carnitine O octanoyltransferase;OCTC_HUMAN;Peroxisomal carnitine acyltransferase;Peroxisomal carnitine O octanoyltransferase;OTTHUMP00000161500;OTTHUMP00000205461;OTTHUMP00000205463
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Wheat Germ
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- Insect Cell
- Mammalian cells
- HEK293
- In Vitro Cell Free System
- E.coli
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CROT involved in several pathways and played different roles in them. We selected most pathways CROT participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CROT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | MLYCD,PEX2,ACSL1,PEX11A,HACL1,NUDT12,HMGCL,ACAA1,NUDT7,PEX5L |
Protein Function
CROT has several biochemical functions, for example, carnitine O-octanoyltransferase activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CROT itself. We selected most functions CROT had, and list some proteins which have the same functions with CROT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | TRIM24,Ren1,NPPC,NTF7,LAMA3,HAO2,CDH5,GLA,Ar,RSPO3 |
Interacting Protein
CROT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CROT here. Most of them are supplied by our site. Hope this information will be useful for your research of CROT.
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References
- Carlson, P; Van Beneden, RJ; et al. Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio). AQUATIC TOXICOLOGY 153:66-72(2014).
- Chen, LW; Zhang, JH; et al. Engineering the Saccharomyces cerevisiae beta-Oxidation Pathway to Increase Medium Chain Fatty Acid Production as Potential Biofuel. PLOS ONE 9:-(2014).
