CPT1B
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Official Full Name
carnitine palmitoyltransferase 1B (muscle) -
Overview
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. -
Synonyms
CPT1B;carnitine palmitoyltransferase 1B (muscle);carnitine O-palmitoyltransferase 1, muscle isoform;CPT1 M;M CPT1;carnitine palmitoyltransferase I-like protein;carnitine O-palmitoyltransferase I, mitochondrial muscle isoform;CPTI;CPT1M;MCPT1;CPT
Recombinant Proteins
- Rhesus macaque
- Human
- Zebrafish
- Mouse
- Cynomolgus
- Mus musculus
- Rat
- Bovine
- Sus scrofa (Pig)
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- His
- His&T7
- GST
- Non
- His&Fc&Avi
Involved Pathway
CPT1B involved in several pathways and played different roles in them. We selected most pathways CPT1B participated on our site, such as AMPK signaling,AMPK signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPT1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty Acid Beta Oxidation | DECR1,CPT2,ECI1,CRAT,CPT1A,CHKB,SLC25A20 |
| FOXA2 and FOXA3 transcription factor networks | UCP2,CPT1C,CPT1A,TTR,CEBPA,FOXF1,DLK1,FOXA1,KCNJ11 |
| AMPK signaling pathway | PRKAB1,PCK2,AKT3,RAB8A,INSR,PIK3R1,CAMKK1,PFKM,PPP2CA,IRS1 |
| AMPK signaling | LOC729991,PPARGC1B,CPT1C,ADRa1A,INS-IGF2,SLC2A4RG,CPT1A,CAMKK2,EEF2,EIF4EBP1 |
| Fatty acid degradation | HADHAA,ALDH2,CYP4A12A,HADH,ACAA1,ACAA1A,HADHA,ACSL4B,ACAT1,ALDH9A1B |
| Adipocytokine signaling pathway | TNFRSF1B,SLC2A4,PRKAB2,SLC2A1,AKT2,PRKAB1,ADIPOR1B,PTPN11A,PRKAG2A,LEP |
| Fatty acid, triacylglycerol, and ketone body metabolism | ELOVL1A,ESRRA,MED26,MMAA,ACOT2,ACOT8,APOA5,MED22,G0S2,ACOT11A |
| Fatty acid metabolism | HADHA,TECRB,SCD5,ACSL3A,CPT2,HADH,TECR,Scd2,SCD,ACADSB |
Protein Function
CPT1B has several biochemical functions, for example, carnitine O-palmitoyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPT1B itself. We selected most functions CPT1B had, and list some proteins which have the same functions with CPT1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carnitine O-palmitoyltransferase activity | CPT2,CPT1A,CPT1C |
| protein binding | NFYC,RUNX2,PINK1,UGGT2,CARD11,PHLPP1,APOA1BP,C1orf105,ARMCX5-GPRASP2,CYSLTR1 |
Interacting Protein
CPT1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPT1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CPT1B.
C2orf57
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References
- Gao, S; McMillan, RP; et al. Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin. DIABETES 63:3242-3252(2014).
- Gomez-Gomez, E; Rios-Martinez, ME; et al. Carnitine Palmitoyltransferase 1B 531K Allele Carriers Sustain a Higher Respiratory Quotient after Aerobic Exercise, but beta 3-Adrenoceptor 64R Allele Does Not Affect Lipolysis: A Human Model. PLOS ONE 9:-(2014).
