CPSF6
-
Official Full Name
cleavage and polyadenylation specific factor 6, 68kDa -
Overview
The protein encoded by this gene is one subunit of a cleavage factor required for 3 RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3 end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. -
Synonyms
CPSF6;cleavage and polyadenylation specific factor 6, 68kDa;cleavage and polyadenylation specific factor 6, 68kD subunit;cleavage and polyadenylation specificity factor subunit 6;CFIM;CFIM68;HPBRII 4;HPBRII 7;Cleavage and polyadenylation specificity factor 68 kDa subunit;CPSF 68 kDa subunit;Pre mRNA cleavage factor Im 68 kDa subunit;Protein HPBRII 4/7;OTTHUMP00000240851;OTTHUMP00000240853;OTTHUMP00000240854;protein HPBRII-4/7;pre-mRNA cleavage factor Im (68kD);pre-mRNA cleavage factor I, 68kD subunit;pre-mRNA cleavage factor;HPBRII-4;HPBRII-7
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Mamanlian cells
- HEK293T
- GST
- Myc&DDK
- His
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPSF6-11540H | Recombinant Human CPSF6, GST-tagged | E.coli | Human | GST | 1-351a.a. | |
| CPSF6-1178H | Recombinant Human CPSF6 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| CPSF6-1848H | Recombinant Human CPSF6 protein, GST-tagged | Wheat Germ | Human | GST | 37-136 a.a. |
|
| CPSF6-1849H | Recombinant Human CPSF6 protein, GST-tagged | Wheat Germ | Human | GST | 1-478 a.a. |
|
| CPSF6-2629Z | Recombinant Zebrafish CPSF6 | Mammalian Cell | Zebrafish | His |
|
|
| CPSF6-3335C | Recombinant Chicken CPSF6 | Mammalian Cell | Chicken | His |
|
|
| CPSF6-3864M | Recombinant Mouse CPSF6 Protein | Mammalian Cell | Mouse | His |
|
|
| CPSF6-1354HFL | Recombinant Full Length Human CPSF6 protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
|
| CPSF6-1945M | Recombinant Mouse CPSF6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| CPSF6-1945M-B | Recombinant Mouse CPSF6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| Cpsf6-2297M | Recombinant Mouse Cpsf6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| CPSF6-876H | Recombinant Human CPSF6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
Involved Pathway
CPSF6 involved in several pathways and played different roles in them. We selected most pathways CPSF6 participated on our site, such as Disease,Diseases of signal transduction,FGFR1 mutant receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by FGFR1 in disease | CUX1,MYO18A,TRIM24,FGFR1OP2 |
| FGFR1 mutant receptor activation | FGFR1OP,FGFR1OP2,CUX1,TRIM24,MYO18A,LRRFIP1 |
| Disease | WHSC2,gag,ANTXR1,AP2A1,HDAC6,OPN1SW,KPNA3,CFTR,MMAA,GYG2 |
| mRNA surveillance pathway | PABPC1,NCBP1,GSPT2,NXF3,WDR33,CPSF2,CPSF5,RBM8A,PPP2R2A,MAGOHB |
| Signaling by FGFR1 fusion mutants | FGFR1OP2,CUX1,TRIM24,MYO18A |
| Signaling by FGFR in disease | FGFR1OP2,TRIM24,MYO18A,LRRFIP1,CUX1 |
| Diseases of signal transduction | TNKS,FKBP1A,TTR,OS9,CUX1,JAG2,RNF43,FGFR1OP2,CTBP2,RLBP1 |
Protein Function
CPSF6 has several biochemical functions, for example, contributes_to RNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF6 itself. We selected most functions CPSF6 had, and list some proteins which have the same functions with CPSF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA binding | LSM7,SMX5,NUDT21 |
| nucleotide binding | SRSF1A,GC2,LEMD3,SLTM,NXF1,HNRPDL,MATR3L,UPF3A,RHOBTB2A,STK24A |
| protein binding | MAP2K7,FAN1,DMBT1,HEMGN,TMED9,TRIM38,FLAD1,TBKBP1,OBFC1,FANCB |
| mRNA binding | AGO2,NUDT21,CELF1,EIF4ENIF1,IGF2BP2A,RBM38,C1QBP,FMR1,RPS5,PAIP2 |
| poly(A) RNA binding | RBM38,EXOSC8,CDKN2A,UBFD1,LRPPRC,MYH9,ETF1,MRPL9,CCBL2,DKC1 |
Interacting Protein
CPSF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF6.
NUDT21;ARMC7;WWP1;TOLLIP;OTUB2;PPIL1
Resources
Related Services
Related Products
References
- Sowalsky, AG; Xia, Z; et al. Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer. MOLECULAR CANCER RESEARCH 13:98-106(2015).
- Shi, J; Zhou, J; et al. Compensatory Substitutions in the HIV-1 Capsid Reduce the Fitness Cost Associated with Resistance to a Capsid-Targeting Small-Molecule Inhibitor. JOURNAL OF VIROLOGY 89:208-219(2015).
