CPSF3
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Official Full Name
cleavage and polyadenylation specific factor 3, 73kDa -
Overview
Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and;polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity;factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 (PubMed;17128255)). -
Synonyms
CPSF3;cleavage and polyadenylation specific factor 3, 73kDa;cleavage and polyadenylation specific factor 3, 73kD subunit;cleavage and polyadenylation specificity factor subunit 3;CPSF 73;CPSF73;YSH1;Cleavage and polyadenylation specificity factor 73 kDa subunit;CPSF;OTTHUMP00000115483;OTTHUMP00000214089;CPSF 73 kDa subunit;mRNA 3-end-processing endonuclease CPSF-73;cleavage and polyadenylation specificity factor 3;cleavage and polyadenylation specificity facto;CPSF-73
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPSF3-11537H | Recombinant Human CPSF3, GST-tagged | E.coli | Human | GST | C-term-348a.a. | |
| CPSF3-1127Z | Recombinant Zebrafish CPSF3 | Mammalian Cell | Zebrafish | His |
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| CPSF3-1812H | Recombinant Human CPSF3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CPSF3-7304HCL | Recombinant Human CPSF3 293 Cell Lysate | HEK293 | Human | Non |
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| CPSF3-1458H | Recombinant Human CPSF3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CPSF3-2154HF | Recombinant Full Length Human CPSF3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 684 amino acids |
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| CPSF3-655H | Recombinant Human CPSF3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| CPSF3-655H-B | Recombinant Human CPSF3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| CPSF3-699HFL | Recombinant Full Length Human CPSF3 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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Involved Pathway
CPSF3 involved in several pathways and played different roles in them. We selected most pathways CPSF3 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | ALYREF,PPP1CAB,MAGOH,MSI2B,SMG1,PABPC1L2A,HBS1L,PPP1CBL,MAGOHB,PPP2R1A |
Protein Function
CPSF3 has several biochemical functions, for example, 5-3 exonuclease activity,RNA binding,endoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF3 itself. We selected most functions CPSF3 had, and list some proteins which have the same functions with CPSF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | NANOS3,NHP2L1B,KHDRBS3,PTBP2A,TERT,RPL34,CELF5,RPL38,NOM1,ADARB1 |
| endoribonuclease activity | RCL1,ENDOU,DROSHA,RNASET2,DICER1,AGO2,PLD6,RNASEKA,RNASEKB,ERN1 |
| 5-3 exonuclease activity | DOM3Z,POLN,DCLRE1C,DXO,FEN1,XRN2,FAN1,EXO1 |
| metal ion binding | ZFP503,FAH,DSG1A,NUPL2,LMAN2,NRXN2B,NT5C3L,ARSG,FBP2,GTF3AA |
| protein binding | HSPB2,AIDA,NKRF,ANKRD54,ACTR8,TLR3,ACOT7,RAD51,CNOT4,TBX1 |
Interacting Protein
CPSF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF3.
SYMPK;CPSF2;WWOX;GSTK1;HSPB1;ssdna_dtdg;P4HA2;KIF21B;CPSF4;NPM1;P4HB
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References
- Gotoh, M; Ichikawa, H; et al. Comprehensive Exploration of Novel Chimeric Transcripts in Clear Cell Renal Cell Carcinomas Using Whole Transcriptome Analysis. GENES CHROMOSOMES & CANCER 53:1018-1032(2014).
- Li, CL; Wang, XL; et al. Microarray analysis revealed that immunity-associated genes are primarily regulated by roxarsone in promoting broiler chicken (Gallus gallus domesticus) growth. POULTRY SCIENCE 91:3184-3190(2012).
