CPN1

  • Official Full Name

    carboxypeptidase N, polypeptide 1

  • Overview

    Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.

  • Synonyms

    CPN1;carboxypeptidase N, polypeptide 1;carboxypeptidase N, polypeptide 1, 50kD;carboxypeptidase N catalytic chain;anaphylatoxin inactivator;arginine carboxypeptidase;carboxypeptidase K;kininase I;lysine carboxypeptidase;kininase-1;serum carboxyp

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Rat
  • Human
  • Chicken
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • Insect cells
  • His
  • His&GST
  • GST
  • Non
  • His&Fc&Avi
  • His&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CPN1-12039Z Recombinant Zebrafish CPN1 Mammalian Cell Zebrafish His
Cpn1-1439M Recombinant Mouse Cpn1 protein, His & GST-tagged E.coli Mouse His&GST Val221~Ala449
CPN1-1568R Recombinant Rat CPN1 Protein Mammalian Cell Rat His
CPN1-1791H Recombinant Human CPN1 Protein, GST-tagged Wheat Germ Human GST
CPN1-3844M Recombinant Mouse CPN1 Protein Mammalian Cell Mouse His
CPN1-4753C Recombinant Chicken CPN1 Mammalian Cell Chicken His
CPN1-847H Recombinant Human CPN1 Protein, His-tagged E.coli Human His
CPN1-7310HCL Recombinant Human CPN1 293 Cell Lysate HEK293 Human Non
CPN1-1225R Recombinant Rat CPN1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CPN1-1225R-B Recombinant Rat CPN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
CPN1-1796H Recombinant Human CPN1 Protein (Leu159-Leu325), N-His tagged E.coli Human His Leu159-Leu325
CPN1-1931M Recombinant Mouse CPN1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CPN1-1931M-B Recombinant Mouse CPN1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CPN1-2097HF Recombinant Full Length Human CPN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 458 amino acids
CPN1-2723H Recombinant Human CPN1 protein, His&Myc-tagged E.coli Human His&Myc 21-458aa
CPN1-3532H Recombinant Human CPN1 protein E.coli Human Non 21-418aa
CPN1-3533H Recombinant Human CPN1 protein E.coli Human Non 21-458aa
CPN1-5222H Recombinant Human CPN1 protein, His-tagged Insect cells Human His 21-458aa
CPN1-8437H Recombinant Human CPN1 protein, His-tagged E.coli Human His 21-458aa

    Involved Pathway

    CPN1 involved in several pathways and played different roles in them. We selected most pathways CPN1 participated on our site, such as Insulin processing,Metabolism of proteins,Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins MAGT1,ASNA1,SENP5,EXOC6,SEC23IP,GCNT3,DNAJB9,SPON1A,COX17,NAT8
    Prostate Cancer IKBKG,IKBKB,BCL2,AKT1,SRD5A2,PIK3R2,SMARCA4,MTOR,TGFA,Ar
    Steroid biosynthesis CYP51,SC4MOL,SOAT2,CELL,SOAT1,MSMO1,SQLE,CEL.1,FAXDC2,NSDHL
    Insulin processing PCSK2,SLC30A8,EXOC8,RAB27A,EXOC3,CPE,EXOC1,SLC30A6,EXOC5,KIF5A
    Peptide hormone metabolism ACE,RAB27A,INHA,GRP,INHBAA,SLC30A6,SPCS3,GPR120,CPA3,ATP6AP2

    Protein Function

    CPN1 has several biochemical functions, for example, metallocarboxypeptidase activity,serine-type carboxypeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPN1 itself. We selected most functions CPN1 had, and list some proteins which have the same functions with CPN1. You can find most of the proteins on our site.

    Function Related Protein
    serine-type carboxypeptidase activity DPP7,CTSA,CPD,SENP2,CPVL,CPE,PRCP,CPDB,CPM,SCPEP1
    zinc ion binding PDLIM3A,ZFAND5,RNF149,MMP23B,ADH1,ENPP2,NUP153,ZC3HC1,S100B,ZNF385A
    metallocarboxypeptidase activity CPA4,CPM,AGBL4,CPA5,CPA6,AGBL5,AEBP1,PEPD,FOLH1,CPA1

    Interacting Protein

    CPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPN1.

    CDC42;CLEC4G

    Resources

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