COX7A2L
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Official Full Name
cytochrome c oxidase subunit VIIa polypeptide 2 like -
Overview
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. -
Synonyms
COX7A2L;cytochrome c oxidase subunit VIIa polypeptide 2 like;cytochrome c oxidase subunit 7A-related protein, mitochondrial;COX7AR;COX7RP;EB1;SIG81;COX7a related protein;Cytochrome c oxidase subunit VIIa related protein, mitochondrial;Estrogen receptor binding CpG island;COX7a-related protein;cytochrome c oxidase subunit VII-related protein;cytochrome c oxidase subunit VIIa-related protein
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COX7A2L-11501H | Recombinant Human COX7A2L, His-tagged | E.coli | Human | His | 1-114a.a. | |
| COX7A2L-16H | Recombinant Human COX7A2L protein, His-tagged | E.coli | Human | His |
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| COX7A2L-1761H | Recombinant Human COX7A2L Protein, GST-tagged | Wheat Germ | Human | GST |
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| COX7A2L-4970C | Recombinant Chicken COX7A2L | Mammalian Cell | Chicken | His |
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| COX7A2L-4971C | Recombinant Chicken COX7A2L | Mammalian Cell | Chicken | His |
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| COX7A2L-995R | Recombinant Rhesus monkey COX7A2L Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| COX7A2L-7325HCL | Recombinant Human COX7A2L 293 Cell Lysate | HEK293 | Human | Non |
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| COX7A2L-2015HF | Recombinant Full Length Human COX7A2L Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 114 amino acids |
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| COX7A2L-2717H | Recombinant Human COX7A2L protein, GST-tagged | E.coli | Human | GST | 1-114aa |
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| COX7A2L-820R | Recombinant Rhesus Macaque COX7A2L Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| COX7A2L-820R-B | Recombinant Rhesus Macaque COX7A2L Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
COX7A2L involved in several pathways and played different roles in them. We selected most pathways COX7A2L participated on our site, such as Oxidative phosphorylation,Cardiac muscle contraction,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with COX7A2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | NDUFA7,CREB3L1,COX7A1,NDUFB6,DCTN1,NDUFB3,COX7C,COX7A2,HIP1,PLCB3 |
| Non-alcoholic fatty liver disease (NAFLD) | SDHD,NDUFA11,CDC42,NDUFV3,UQCRH,PIK3R2,XBP1,MAPK8,NDUFS1,FASLG |
| Cardiac muscle contraction | CACNA1D,COX5B2,ATP2A2,CACNG2,CACNA2D3,CACNA2D2,VMHC,ACTC1,TPM1,COX4I2 |
| Oxidative phosphorylation | COX17,COX5A,MT-ATP6,COX6A2,ATP6V0A1A,COX7B,NDUFB7,NDUFA9A,NDUFS8B,ATP6V1C2 |
| Parkinsons disease | NDUFS6,SLC25A31,NDUFA9,UCHL1,SEPT5,PRKACB,SDHC,CYCS,VDAC1,COX8C |
| Alzheimers disease | NDUFC2-KCTD14,NDUFB8,ERN1,UQCR11,NOS1,NDUFB6,PPP3R2,ATP5C1,MAPT,ATP5H |
Protein Function
COX7A2L has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX7A2L itself. We selected most functions COX7A2L had, and list some proteins which have the same functions with COX7A2L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | COX11,COX6B1,CYB5A,SURF1,COX4I1,COX6A1,COX6B2,COX5AA,COX7B,COX7B2 |
Interacting Protein
COX7A2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX7A2L here. Most of them are supplied by our site. Hope this information will be useful for your research of COX7A2L.
MAGEA11;NDUFS4;NDUFS5;TIMMDC1
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