COX6B1
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Official Full Name
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -
Overview
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. -
Synonyms
COX6B1;cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous);COX6B, cytochrome c oxidase subunit Vib , cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous);cytochrome c oxidase subunit 6B1;COXG;COX VIb-1;COX6B;COXVIb1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
COX6B1 involved in several pathways and played different roles in them. We selected most pathways COX6B1 participated on our site, such as Alzheimers disease,Cardiac muscle contraction,Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Electron Transport Chain | SURF1,NDUFS7,COX6A2,ATP5S,NDUFC2-KCTD14,COX4I1,COX17,COX15,COX7C,COX5B |
| Metabolic pathways | PNMT,CES1,CBR1,ATP6V1A,ST6GALNAC4,PNLIPRP1,HSD17B2,ITPKB,PI4K2A,glpK |
| Gene Expression | SNRNP48,ZNF493,SESN3,ZNF354B,SAP30L,CCDC76,MED26,SMG8,NR2C2,EEF1G |
| Huntingtons disease | COX6B2,GNAQ,NDUFB2,REST,COX4I2,GRM5,ATP5O,NDUFA13,SIN3A,NDUFAB1 |
| Metabolism | TIMMDC1,NOSTRIN,CSPG5B,OAZ2,HS3ST6,CERS5,ACOT9.2,AK7A,CYP2AD2,DCT |
| Cardiac muscle contraction | ATP1B3B,CACNG6A,MYL2,CACNA1SB,CACNB3,VMHC,MYL3,COX6B2,ATP2A2,UQCRC2 |
| Alzheimers disease | COX8A,COX6C,ATP2A3,NDUFS7,NDUFB7,COX5A,TNF,NDUFC2,BACE1,FAS |
| Generic Transcription Pathway | SESN3,ZNF561,ZNF550,NR5A1A,ZNF436,ZNF480,CCNT2B,NR2C1,ZNF213,ZNF354B |
Protein Function
COX6B1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6B1 itself. We selected most functions COX6B1 had, and list some proteins which have the same functions with COX6B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | COX4I1,COX5B2,COX7A3,COX7A1,COX6A2,COX8C,COX7A2L,COX15,CYB5A,COX6C |
Interacting Protein
COX6B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6B1.
env;40038273;MT-CO2;VPS26A;Zbtb7a;Cdc6;YEATS4;XRCC5;Rab5c;HTT;RAB5C;POLR2G;TMEM132A;Ankfy1;Sidt2;YIPF5;TIMMDC1;VAPA
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References
- Lim, J; Liu, ZB; et al. Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet. PLOS ONE 9:-(2014).
- Abdulhag, UN; Soiferman, D; et al. Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy. EUROPEAN JOURNAL OF HUMAN GENETICS 23:159-164(2015).
