COX10

  • Official Full Name

    COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

  • Overview

    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

  • Synonyms

    COX10;COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast);COX10 (yeast) homolog, cytochrome c oxidase assembly protein (heme A: farnesyltransferase);protoheme IX farnesyltransferase, mitochondrial;mitochondrial;2410004F01Rik;AU042636;COX10_HUMAN;Cytochrome c oxidase assembly protein;Cytochrome c oxidase subunit X;Heme A farnesyltransferase;Heme O synthase;OTTMUSP00000006085;Protoheme IX farnesyltransferase;Protoheme IX farnesyltransferase, mitochondrial precursor;RP23-78H18.1;heme A: farnesyltransferase

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Rhesus macaque
  • Kluyveromyces lactis
  • Ashbya gossypii
  • Yarrowia lipolytica
  • Neosartorya fumigata
  • Wheat Germ
  • Mammalian Cells
  • In Vitro Cell Free System
  • HEK293
  • E.coli
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
COX10-1732H Recombinant Human COX10 Protein, GST-tagged Wheat Germ Human GST
COX10-2403C Recombinant Chicken COX10 Mammalian Cells Chicken His
COX10-7606Z Recombinant Zebrafish COX10 Mammalian Cells Zebrafish His
COX10-980R Recombinant Rhesus monkey COX10 Protein, His-tagged Mammalian Cells Rhesus macaque His
COX10-387HCL Recombinant Human COX10 cell lysate Human Non
COX10-1992HF Recombinant Full Length Human COX10 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 443 amino acids
COX10-805R Recombinant Rhesus Macaque COX10 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
COX10-805R-B Recombinant Rhesus Macaque COX10 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RFL10864KF Recombinant Full Length Kluyveromyces Lactis Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged E.coli Kluyveromyces lactis His Full L. Full Length of Mature Protein (28-452)
RFL26004AF Recombinant Full Length Ashbya Gossypii Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged E.coli Ashbya gossypii His Full L. Full Length of Mature Protein (36-435)
RFL26612YF Recombinant Full Length Yarrowia Lipolytica Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged E.coli Yarrowia lipolytica His Full L. Full Length (61-471)
RFL70NF Recombinant Full Length Neosartorya Fumigata Protoheme Ix Farnesyltransferase, Mitochondrial(Cox10) Protein, His-Tagged E.coli Neosartorya fumigata His Full L. Full Length of Mature Protein (48-512)

    Involved Pathway

    COX10 involved in several pathways and played different roles in them. We selected most pathways COX10 participated on our site, such as Heme biosynthesis,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Porphyrin and chlorophyll metabolism UGT2B15,HCCS,UGT1A7C,UGT1A6A,ALAS1,ALAD,PPOX,UGT2B7,MMAB,UGT2A2
    Heme biosynthesis COX15,CPOX
    Metabolic pathways ST6GAL2,ATP5H,PGAM1A,STT3A,P4HA1,B3GALT5,PTDSS2,HSD17B8,URAH,SDHA
    Metabolism of porphyrins CPOX,UGT1B4,UGT1B1,UGT1B5,UGT1B3,UGT1B7,UGT1B2,COX15
    Oxidative phosphorylation NDUFS5,ATP6V1E1,ATP6V1H,ATP6V0CB,PPA2,ATP5D,NDUFA9A,NDUFB11,ATP6V0E1,NDUFS8
    Metabolism ACOT13,AQP1A.1,AK8,INSIG2,NEU3,SREBF2,MED10,NDUFAF7,GCKR,B3GNT2A

    Protein Function

    COX10 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity,farnesyltranstransferase activity,protoheme IX farnesyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX10 itself. We selected most functions COX10 had, and list some proteins which have the same functions with COX10. You can find most of the proteins on our site.

    Function Related Protein
    protoheme IX farnesyltransferase activity UBIAD1
    farnesyltranstransferase activity GGPS1,FNTB
    contributes_to cytochrome-c oxidase activity COX15,NDUFA4

    Interacting Protein

    COX10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX10 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX10.

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