COPS3
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Official Full Name
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) -
Overview
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
COPS3;COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis);COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3;COP9 signalosome complex subunit 3;CSN3;SGN3;signalosome subunit 3;COP9 complex subunit 3;JAB1-containing signalosome subunit 3
Recombinant Proteins
- Zebrafish
- Chicken
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COPS3-10083Z | Recombinant Zebrafish COPS3 | Mammalian Cell | Zebrafish | His |
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| COPS3-1314C | Recombinant Chicken COPS3 | Mammalian Cell | Chicken | His |
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| COPS3-1533R | Recombinant Rat COPS3 Protein | Mammalian Cell | Rat | His |
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| COPS3-1702H | Recombinant Human COPS3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COPS3-3780M | Recombinant Mouse COPS3 Protein | Mammalian Cell | Mouse | His |
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| COPS3-7358HCL | Recombinant Human COPS3 293 Cell Lysate | HEK293 | Human | Non |
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| COPS3-1190R | Recombinant Rat COPS3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COPS3-1190R-B | Recombinant Rat COPS3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| COPS3-1887M | Recombinant Mouse COPS3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COPS3-1887M-B | Recombinant Mouse COPS3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COPS3-1955HF | Recombinant Full Length Human COPS3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 423 amino acids |
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Involved Pathway
COPS3 involved in several pathways and played different roles in them. We selected most pathways COPS3 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | KTN1,DDX3X,TRAIP,FAF1,CRADD,RNF216,KIAA1967,PDCD2,KPNA6,COMMD1 |
| Global Genome Nucleotide Excision Repair (GG-NER) | ACTL6A,INO80C,COPS7B,MCRS1,TFPT,COPS7A,INO80B,GPS1,COPS8,COPS4 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | KIAA1530,ZNF830,ERCC8,COPS7A,COPS8,COPS7B,COPS4,GPS1,PPIE,COPS6 |
| DNA Repair | UBE2L6,USP10,RNF111,PAXIP1,ACTR5,WRN,RIF1,ASCC2,EYA3,INO80C |
| Nucleotide Excision Repair | RFC5,RBX1,POLD4,MCRS1,POLE2,RAD23A,ZFP830,ERCC2,RFC1,GTF2H2C_2 |
| Formation of TC-NER Pre-Incision Complex | PPIE,ZNF830,ERCC8,COPS7B,COPS7A,COPS8,COPS6,COPS5,TCEA1,ZFP830 |
| DNA Damage Recognition in GG-NER | CETN2,TFPT,INO80C,INO80E,GPS1,COPS7A,COPS7B,COPS8,ACTR5,DDB1 |
Protein Function
COPS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS3 itself. We selected most functions COPS3 had, and list some proteins which have the same functions with COPS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EDNRA,DLGAP4,SH3YL1,MYO7A,PSMC1,RALB,FGF19,PLEKHG4,UBE2D2,SMN2 |
Interacting Protein
COPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS3.
COPS5;COPS6;COPS7A
Resources
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References
- McMichael, G; Girirajan, S; et al. Rare copy number variation in cerebral palsy. EUROPEAN JOURNAL OF HUMAN GENETICS 22:40-45(2014).
- Goossens, DJ; Brazier-Hollins, S; et al. Magnetic structure and glassiness in Fe0.5Ni0.5PS3. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 334:82-86(2013).
