COPS2
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Official Full Name
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) -
Overview
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. -
Synonyms
COPS2;COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis);COP9 signalosome complex subunit 2;ALIEN;CSN2;TRIP15;Alien homolog;COP 9;COP9;COP9 constitutive photomorphogenic homolog subunit 2;COPS 2;CSN2_HUMAN;JAB1 containing signalosome subunit 2;JAB1-containing signalosome subunit 2;SGN 2;SGN2;Signalosome subunit 2;ThyroidHormone Receptor Interactor15;Thyroid Hormone Receptor Interactor 15;Thyroid receptor-interacting protein 15;TR-interacting protein 15;TRIP 15;TRIP-15;thyroid receptor interacting protein 15
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- Yeast
- HEK293T
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
COPS2 involved in several pathways and played different roles in them. We selected most pathways COPS2 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | COPS8,EYA2,UBE2V2,SMARCA5,CETN2,PPP4R2B,INO80B,BABAM1,PNKP,RAD9A |
| DNA Damage Recognition in GG-NER | COPS7B,ACTL6A,COPS6,MCRS1,YY1A,INO80E,CETN2,ACTR5,NFRKB,COPS8 |
| Global Genome Nucleotide Excision Repair (GG-NER) | COPS8,INO80C,INO80B,PIAS3,DDB2,ACTL6A,USP45,TFPT,COPS3,CHD1L |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | COPS8,COPS7B,ZNF830,COPS4,PPIE,COPS6,COPS3,ZFP830,ERCC8,KIAA1530 |
| Nucleotide Excision Repair | ERCC5,PCNA,NFRKB,COPS8,POLE3,COPS5,RPA3,ZNF830,YY1,ERCC1 |
| Formation of TC-NER Pre-Incision Complex | ZNF830,PPIE,COPS7A,TCEA1,DDB1,GPS1,COPS6,COPS8,COPS3,COPS5 |
Protein Function
COPS2 has several biochemical functions, for example, protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS2 itself. We selected most functions COPS2 had, and list some proteins which have the same functions with COPS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | OLFR474,OLFR470,PLCB2,TAS2R118,PLCB1,S1PR3A,EEF1D,MTNR1AA,GULP1,OMP |
| protein binding | RAD23A,FCNA,SPDYE2,SFPI1,ANXA9,FRK,POLR2C,EMX2,YTHDF3,CARD9 |
Interacting Protein
COPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS2.
GFER;EP300;Dtl;COPS5;COPS3;Crebbp
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