COL8A2
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Official Full Name
collagen, type VIII, alpha 2 -
Overview
This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. -
Synonyms
COL8A2;collagen, type VIII, alpha 2;FECD;collagen alpha-2(VIII) chain;PPCD;PPCD2;FLJ00201;MGC116970;MGC116972;AI429819;FECD1;MGC90765;RP23-113P22.2;RP4-665N4.3;endothelial collagen;collagen VIII, alpha-2 polypeptide;dJ665N4.1 (collagen type VIII alpha 2)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL8A2-1661H | Recombinant Human COL8A2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COL8A2-5276Z | Recombinant Zebrafish COL8A2 | Mammalian Cells | Zebrafish | His |
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| COL8A2-7886H | Recombinant Human COL8A2 protein, His-tagged | E.coli | Human | His | Asp537~Thr703 |
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| Col8a2-7887M | Recombinant Mouse Col8a2 protein, His-tagged | E.coli | Mouse | His | Asp533~Pro698 |
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| COL8A2-7375HCL | Recombinant Human COL8A2 293 Cell Lysate | HEK293 | Human | Non |
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| COL8A2-1771H | Recombinant Human COL8A2 Protein (Gln396-Thr703), N-His tagged | E.coli | Human | His | Gln396-Thr703 |
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| COL8A2-2180HF | Recombinant Full Length Human COL8A2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 427 amino acids |
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| Col8a2-2244M | Recombinant Mouse Col8a2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| COL8A2-4491H | Recombinant Human COL8A2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
COL8A2 involved in several pathways and played different roles in them. We selected most pathways COL8A2 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes,Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL8A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | COL19A1,NID1,FN1B,COL28A1A,TRAPPC4,VCANB,MMP8,MMP13,COL5A3B,MMP12 |
| Collagen formation | CD151,PCOLCEB,COL23A1,COL6A3,PPIB,COL10A1,COL15A1B,COL1A1,LOXL2,TLDC2 |
| Assembly of collagen fibrils and other multimeric structures | COL8A1,COL10A1,COL4A3,MMP20,COL2A1,CD151,MMP13,DST,PCOLCE,PLEC |
| Collagen biosynthesis and modifying enzymes | COL5A1,COL1A2,ADAMTS3,COL4A4,PCOLCE2,COL25A1,COL4A6,COL6A2,PCOLCEB,SERPINH1 |
Protein Function
COL8A2 has several biochemical functions, for example, extracellular matrix structural constituent,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by COL8A2 itself. We selected most functions COL8A2 had, and list some proteins which have the same functions with COL8A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL1A1,MEPE,COL3A1,COL4A6,COL11A1A,COL1A2,FBLN1,CHI3L1,TINAGL1,COL11A1B |
| protein binding, bridging | CAV1,IVL,SPRR1A,CRADD,NEFL,FLRT1,TJP2,TRIM5,ANK2,STX1A |
Interacting Protein
COL8A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL8A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL8A2.
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