COL4A6
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Official Full Name
collagen, type IV, alpha 6 -
Overview
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. -
Synonyms
COL4A6;collagen, type IV, alpha 6;collagen alpha-6(IV) chain;collagen alpha 6 type IV;collagen IV, alpha-6 polypeptide;dJ889N15.4 (Collagen Alpha 6(IV));collagen of basement membrane, alpha-6;DELXq22.3;CXDELq22.3;MGC88184
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL4A6-11436H | Recombinant Human COL4A6, GST-tagged | E.coli | Human | GST | 1-73a.a. | |
| COL4A6-1654H | Recombinant Human COL4A6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COL4A6-2165HF | Recombinant Full Length Human COL4A6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 73 amino acids |
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| COL4A6-2866H | Recombinant Human COL4A6 protein(1101-1460 aa), C-His-tagged | E.coli | Human | His | 1101-1460 aa |
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Involved Pathway
COL4A6 involved in several pathways and played different roles in them. We selected most pathways COL4A6 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of collagen fibrils and other multimeric structures | COL8A1A,LOX,COL6A1,MMP20,MMP13,BMP1,COL1A1,CTSB,TLL1,BMP1A |
| Collagen formation | CTSL1,CTSS,BMP1A,COL8A2,PCOLCE,COL5A2,DST,COL6A2,PCOLCEB,COL1A2 |
| Amoebiasis | GNA15,IFNG,PRKCB,CXCL8,IL1B,RAB7A,PIK3R1,PRKCA,IL12B,PLCB4 |
| Collagen biosynthesis and modifying enzymes | COL15A1B,COL6A3,PCOLCE,ADAMTS3,COL8A1,CRTAP,COL8A2,COL10A1,COL16A1,TLL1 |
| Focal adhesion | RAC2,AASS,ACTN3,PDGFRB,CAPN2B,FN1A,ILK,IGF1,THBS1,PAK2 |
| ECM-receptor interaction | COL1A1A,COL2A1A,COL6A1,ITGA11A,TNXB,COL6A4,LAMA4,FN1,HSPG2,Itga10&Itgb1 |
| Extracellular matrix organization | ADAMTS8,LEPREL1,COL9A1,COL9A1A,LTBP2,SERPINH1,ADAMTS18,MMP12,SERPINH1A,COMP |
Protein Function
COL4A6 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A6 itself. We selected most functions COL4A6 had, and list some proteins which have the same functions with COL4A6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL27A1,COL5A2,COL2A1B,MUC5AC,COL27A1B,PRELP,MFAP5,COL1A1A,MEPE,COL4A5 |
Interacting Protein
COL4A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A6.
KLK6;OSM
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References
- Tveita, AA; Ninomiya, Y; et al. Development of lupus nephritis is associated with qualitative changes in the glomerular collagen IV matrix composition. LUPUS 18:355-360(2009).
- Ikeda, K; Iyama, K; et al. Loss of expression of type IV collagen alpha 5 and alpha 6 chains in colorectal cancer associated with the hypermethylation of their promoter region. AMERICAN JOURNAL OF PATHOLOGY 168:856-865(2006).
