COL4A3BP
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Official Full Name
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -
Overview
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
COL4A3BP;collagen, type IV, alpha 3 (Goodpasture antigen) binding protein;collagen type IV alpha-3-binding protein;ceramide transporter;CERT;GPBP;StAR related lipid transfer (START) domain containing 11;STARD11;hCERT;ceramide transfer protein;li
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cells
- Insect Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL4A3BP-11434H | Recombinant Human COL4A3BP, GST-tagged | E.coli | Human | GST | C-227a.a. | |
| COL4A3BP-1652H | Recombinant Human COL4A3BP Protein, GST-tagged | Wheat Germ | Human | GST |
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| COL4A3BP-2488H | Recombinant Human COL4A3BP, His-tagged | E.coli | Human | His |
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| COL4A3BP-26193TH | Recombinant Human COL4A3BP, His-tagged | E.coli | Human | His | 252 amino acids |
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| COL4A3BP-27223TH | Recombinant Human COL4A3BP, His-tagged | E.coli | Human | His |
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| COL4A3BP-3738M | Recombinant Mouse COL4A3BP Protein | Mammalian Cell | Mouse | His |
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| COL4A3BP-8648H | Recombinant Human COL4A3BP protein, His&GST-tagged | Insect Cells | Human | His&GST | 1-598 a.a. |
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| COL4A3BP-001HCL | Recombinant Human COL4A3BP cell lysate | Insect Cell | Human | Non |
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| COL4A3BP-1865M | Recombinant Mouse COL4A3BP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COL4A3BP-1865M-B | Recombinant Mouse COL4A3BP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COL4A3BP-2164HF | Recombinant Full Length Human COL4A3BP Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 598 amino acids |
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| COL4A3BP-3280H | Recombinant Human COL4A3BP Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
COL4A3BP involved in several pathways and played different roles in them. We selected most pathways COL4A3BP participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | MED19,PITPNB,CYP4F11,ACOT6,GC,MED6,PMVK,COQ7,SREBF2,ALOX5AP |
| Sphingolipid de novo biosynthesis | FA2H,CERS4A,ACER1,CERS5,OSBP,CERS3B,PPM1L,SPTLC1,PPM1LB,SGMS2 |
| Metabolism | UGT1B7,AKR1C4,ACAD11,DBH,APOA4B.2,CTGF,FAM36A,NDUFAF7,CYP27A1,SLC25A16 |
| Sphingolipid metabolism | CERS5,GAL3ST1,UGT8A,ARSF,ARSK,SPTLC2,OSBP,NEU3.4,GLA,PPM1LA |
Protein Function
COL4A3BP has several biochemical functions, for example, ceramide binding,ceramide transporter activity,phosphatidylinositol-4-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3BP itself. We selected most functions COL4A3BP had, and list some proteins which have the same functions with COL4A3BP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C10orf62,NIPA2,RAP1A,TUBA1C,HIST1H3C,CD44,CD24,ERCC3,RECQL4,EFNB1 |
| protein kinase activity | RAF1A,CDC7,PRKAA2,PLK1,CLK2B,PTK2AA,GRK1,GC3,PRKCHA,FYNA |
| ceramide binding | PLEKHA8,PRRC2B |
| phosphatidylinositol-4-phosphate binding | SH3PXD2B,FAM21C,PRRC2B,JPH2,OSBP,PLEKHF1,MBL1,ARFIP2,SESTD1,SNX24 |
Interacting Protein
COL4A3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3BP.
CSNK1G2;ITGB3BP;ARL6IP1;ACTL8;PARP2;PRKAR1A;MARK2;RTN3
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References
- Plaisier, E; Borradori, L; et al. Anti-glomerular basement membrane nephritis and bullous pemphigoid caused by distinct anti-alpha 3(IV)NC1 and anti-BP180 antibodies in a patient with Crohn's disease. AMERICAN JOURNAL OF KIDNEY DISEASES 40:649-654(2002).
- Netzer, KO; Leinonen, A; et al. The Goodpasture autoantigen - Mapping the major conformational epitope(s) of alpha 3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. JOURNAL OF BIOLOGICAL CHEMISTRY 274:11267-11274(1999).
