CNTN1
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Official Full Name
contactin 1 -
Overview
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
CNTN1;contactin 1;contactin-1;F3;glycoprotein gP135;GP135;neural cell surface protein F3
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Rhesus macaque
- E.coli
- Sf21 Insect Cell
- Mammalian Cell
- HEK293
- Human Cell
- HEK293T
- GST
- Fc
- His
- Non
- His&T7
- His&Fc
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CNTN1 involved in several pathways and played different roles in them. We selected most pathways CNTN1 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus,Axon guidance,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | LIMK2,KCNQ3,NRP2,CREB1B,SEMA3D,ROCK1,CLTC,DCX,RASA1,CDK5 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | MDKA,MDKB,MDK,MIB1 |
| Delta-Notch Signaling Pathway | RING1,CNTF,ADAM10A,WDR12,MAGEA1,JAG2,ZFPM1,HES6,SAP30,CNTFR |
| Cell adhesion molecules (CAMs) | PVRL2,Siglec1,ITGA8,JAM2A,CLDNH,PECAM1,CD6,CNTNAP2A,CD28,SELL |
| Activated NOTCH1 Transmits Signal to the Nucleus | DNER,MIB1,JAG2,DTX2,ADAM10,DLK1,JAG1 |
| L1CAM interactions | DPYSL2B,SCN2B,CD24,SDCBP,KIF4A,NADL1.1,NRP2,SCN2A,CNTN6,NRP1A |
| Neurofascin interactions | SDCBP,DCX |
| Developmental Biology | DNM2,MED8,EPHA2,MED22,DPYSL4,PTPRA,COL9A1B,AP2A1,MED6,EPHA10 |
Protein Function
CNTN1 has several biochemical functions, for example, carbohydrate binding,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTN1 itself. We selected most functions CNTN1 had, and list some proteins which have the same functions with CNTN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | CD33,DGCR2,FCN3,REG3A,CLEC2H,ASGR2,NOMO1,REG3B,GALNT4,CDIPT |
| glycoprotein binding | LCK,FBXO2,FYN,SDC1,AZGP1,FBXO6,EDEM2,Serpina1b,SERPINA1A,VIM |
Interacting Protein
CNTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTN1.
PROP1;PPP1CA;MAPK6;HTT
CNTN1 Related Signal Pathway
Resources
Research Area
Notch PathwayNotch Family
Immunoglobulin Superfamily CAMs
Contactins
Synaptic Adhesion Molecules
Related Services
Related Products
References
- Querol, L; Nogales-Gadea, G; et al. Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. ANNALS OF NEUROLOGY 73:370-380(2013).
- Davisson, MT; Bronson, RT; et al. A Spontaneous Mutation in Contactin 1 in the Mouse. PLOS ONE 6:-(2011).
