CNTFR
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Official Full Name
ciliary neurotrophic factor receptor -
Overview
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component;of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival,;differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the;transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal;transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as;well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
CNTFR;ciliary neurotrophic factor receptor;ciliary neurotrophic factor receptor subunit alpha;CNTFR-alpha;CNTF receptor subunit alpha;MGC1774
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- Insect Cells
- Mammalian Cells
- Sf21 Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- GST
- DDK&Myc
- Avi&Fc&His
- Flag
Involved Pathway
CNTFR involved in several pathways and played different roles in them. We selected most pathways CNTFR participated on our site, such as Adipogenesis,Cytokine-cytokine receptor interaction,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | NR2F1A,NRIP1,FRZB,NDN,FOXC2,CREB1,DLK1,MBNL1,GADD45A,KLF5 |
| Cytokine-cytokine receptor interaction | CXCL8,TNFRSF14,TNFRSF25,CCL17,IL22RA1,RNF207B,Ccl9,IFNG1-2,GM2506,IFNA2 |
| Delta-Notch Signaling Pathway | MAGEA1,CNTF,NOV,TUBB3,SAP30,WDR12,HES6,SMAD3B,APPA,TLE1 |
| Jak-STAT signaling pathway | IL5,IL17D,Gh,PRL,IL12A,JAK2A,M17,IFNA13,HRASB,IL22RA2 |
Protein Function
CNTFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity,cytokine binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTFR itself. We selected most functions CNTFR had, and list some proteins which have the same functions with CNTFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ciliary neurotrophic factor receptor activity | IL6R,LIFR,Il6ra |
| cytokine binding | KITB,CRLF1,LIFR,ELANE,PARK7,NRP1,KIT,IL17F,IL31RA,IFNGR1 |
| receptor binding | PVRL2,HLA-E,AGXT,HSD17B4,LBP,IDH1,ENSA,MSTN,F7,PAOX |
Interacting Protein
CNTFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTFR here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTFR.
ABL1;FYN;NCK1;CRK;GRB2;PLSCR1;APPBP2;CRAMP1L;KRTAP4-12
Resources
Research Area
VPS10P-domain FamilyNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
IL-6 Family Receptors
Related Services
Related Products
References
- Lu, J; Ksendzovsky, A; et al. CNTF receptor subunit alpha as a marker for glioma tumor-initiating cells and tumor grade. JOURNAL OF NEUROSURGERY 117:1022-1031(2012).
- Lee, N; Spearry, RP; et al. Muscle ciliary neurotrophic factor receptor promotes axonal regeneration and functional recovery following peripheral nerve lesion. JOURNAL OF COMPARATIVE NEUROLOGY 521:2947-2965(2013).
