CNOT6
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Official Full Name
CCR4-NOT transcription complex, subunit 6 -
Overview
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3-5 RNase activity and prefers polyadenylated substates. -
Synonyms
CNOT6;CCR4-NOT transcription complex, subunit 6;CCR4-NOT transcription complex subunit 6;CCR4;KIAA1194;fa03c11;wu:fc17f01;zgc:65822;A230103N10Rik;AA407540;AW456442;carbon catabolite repression 4 protein;Carbon catabolite repressor protein 4 homolog;CCR4 carbon catabolite repression 4 like;CCR4 carbon catabolite repression 4-like;Cytoplasmic deadenylase;EC 3.1.-.-;fc17f01;MGC98472;OTTHUMP00000161544;wu:fa03c11
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Rhesus macaque
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- His&Fc&Avi
Involved Pathway
CNOT6 involved in several pathways and played different roles in them. We selected most pathways CNOT6 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | DnaK,DHX36,XRN1,EXOSC3,DIS3,ENO1,LSM3,PABPC5,ENO1A,EXOSC2 |
Protein Function
CNOT6 has several biochemical functions, for example, RNA binding,exonuclease activity,exoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT6 itself. We selected most functions CNOT6 had, and list some proteins which have the same functions with CNOT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exoribonuclease activity | EXOSC10,CNOT7 |
| exonuclease activity | REX1,EXO1,AEN,EXO5,REXO1L1,RAD9,WRN,ISG20L2,ISG20,XRN1 |
| metal ion binding | ZFAT,PDE1C,NPAS2,RNF144AB,ZFP239,TNFSF10,ZKSCAN1,ZDHHC5A,NR1D4A,MT1X |
| hydrolase activity | FHIT,DDX3,LYZ1,AGBL4,ASAH1A,KLK1B8,CHD1L,PRSS52,PLCD3A,ENOPH1 |
| poly(A)-specific ribonuclease activity | PDE12,CNOT8,PAN2,TOE1,CNOT7,PARN,CNOT6L |
| nuclease activity | DOM3Z,ZRANB3,ENDOG,SMG6,EAR1,HARBI1,RNASEL4,TMPPE,SND1,ENDOU2 |
| RNA binding | OASL1,KHDC1B,MCTS2,EIF3B,CPSF3,HNRNPK,HNRNPH2,RBMS1,CDKN2AIP,RCAN3 |
Interacting Protein
CNOT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT6.
Cnot7
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