CNOT4
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Official Full Name
CCR4-NOT transcription complex, subunit 4 -
Overview
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CNOT4;CCR4-NOT transcription complex, subunit 4;NOT4;CCR4-NOT transcription complex subunit 4;CLONE243;NOT4H;CCR4-associated factor 4;E3 ubiquitin-protein ligase CNOT4;potential transcriptional repressor NOT4Hp;NOT4 (negative regulator of transcr
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CNOT4-1582H | Recombinant Human CNOT4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CNOT4-2039C | Recombinant Chicken CNOT4 | Mammalian Cell | Chicken | His |
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| CNOT4-7400HCL | Recombinant Human CNOT4 293 Cell Lysate | HEK293 | Human | Non |
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| CNOT4-7401HCL | Recombinant Human CNOT4 293 Cell Lysate | HEK293 | Human | Non |
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| CNOT4-1938HF | Recombinant Full Length Human CNOT4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 565 amino acids |
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| Cnot4-2221M | Recombinant Mouse Cnot4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CNOT4 involved in several pathways and played different roles in them. We selected most pathways CNOT4 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | NUDT16,TOB1B,DnaK,CNOT2,EXOSC6,CNOT3A,PFKM,TOB1,ZCCHC7,MPHOSPH6 |
Protein Function
CNOT4 has several biochemical functions, for example, ligase activity,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT4 itself. We selected most functions CNOT4 had, and list some proteins which have the same functions with CNOT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM35-1,CSRP2,SERPINB1A,ISL2B,MMP23BB,USP22,CAD,LHX3,CAHZ,DRL |
| ubiquitin-protein transferase activity | UBE2D1,UBE2A,TRIM2,UBE2B,RC3H2,CMTM2A,ZFP91,TRIM23,LNX2B,MDM2 |
| poly(A) RNA binding | RPL13A,RPL21,SMNDC1,AATF,TRMT1,PARP1,MBNL1,SBDS,EWSR1,PAN3 |
| ligase activity | CCNB1IP1,TRIP12,HECW1B,MARCH5L,TRIM21,RNF146,SH3RF2,CTPS1A,UBE2KA,UHRF1 |
| nucleotide binding | ATP1A3B,KIF15,HNRNPH1,NCL,TRIM66,GTF2F2B,SAFB,INSRB,RAB14L,SYNJ1 |
| protein binding | ATP2B1,HIST1H3G,NKX2,C19orf25,PLEC,SPANXC,TRA2B,KCTD13,TBX6,FYTTD1 |
Interacting Protein
CNOT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT4.
UBE2D3;UBE2N;UBE2D2;EP300;UBE2E3;UBE2W;UBE2D4;MYC
Resources
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References
- Venturini, G; Rose, AM; et al. CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance. PLOS GENETICS 8:-(2012).
- Babbarwal, V; Fu, JH; et al. The Rpb4/7 Module of RNA Polymerase II Is Required for Carbon Catabolite Repressor Protein 4-Negative on TATA (Ccr4-Not) Complex to Promote Elongation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33125-33130(2014).
