CNOT2
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Official Full Name
CCR4-NOT transcription complex, subunit 2 -
Overview
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
CNOT2;CCR4-NOT transcription complex, subunit 2;NOT2;CCR4-NOT transcription complex subunit 2;CDC36;NOT2H;CCR4 associated factor 2;CCR4 NOT transcription complex subunit 2;CCR4-associated factor 2;HSPC131;MSTP046;NOT2 (negative regulator of transcription 2 yeast) homolog;OTTHUMP00000241224;OTTHUMP00000241234;OTTHUMP00000241236;negative regulator of transcription 2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CNOT2 involved in several pathways and played different roles in them. We selected most pathways CNOT2 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | BTG3,TOB1,XRN2,ENO1A,DCP1A,LSM4,GM5506,EXOSC7,PFKP,PFKMB |
Protein Function
CNOT2 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,RNA polymerase II transcription corepressor binding,contributes_to poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT2 itself. We selected most functions CNOT2 had, and list some proteins which have the same functions with CNOT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | TDG,MED31,TP53BP1,PPRC1,MED15,NKX2-5,FOXH1,MED8,MED22,RBM14 |
| protein binding | BRCA2,NFIX,FAM21C,AMFR,FSHR,FBXO34,CTNNB1,PPIH,CA4,OFCC1 |
| contributes_to poly(A)-specific ribonuclease activity | CNOT1,PAN3 |
Interacting Protein
CNOT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT2.
CNOT1;CNOT3;CNOT6L;CNOT8;TNRC6C;Cnot7;HDAC3;SS18
Resources
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References
- Turowski, TW; et al. The impact of transcription on posttranscriptional processes in yeast. GENE 526:23-29(2013).
- Collart, MA; Panasenko, OO; et al. The Not3/5 subunit of the Ccr4-Not complex: A central regulator of gene expression that integrates signals between the cytoplasm and the nucleus in eukaryotic cells. CELLULAR SIGNALLING 25:743-751(2013).
