CLK2
-
Official Full Name
CDC-like kinase 2 -
Overview
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008] -
Synonyms
CLK2;CDC-like kinase 2;hCLK2;dual specificity protein kinase CLK2;CLK kinase
Recombinant Proteins
- Human
- Chicken
- E.coli
- Sf9 Cells
- Insect Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- GST
- His
- Non
- His&SUMO
- His&B2M
Involved Pathway
CLK2 involved in several pathways and played different roles in them. We selected most pathways CLK2 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | RBMS3,MCTS2,METTL3,DDX20,DHX8,DDX39,SNURF,ZFP346,OASL2,RBM39A |
Protein Function
CLK2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK2 itself. We selected most functions CLK2 had, and list some proteins which have the same functions with CLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AP1G2,TRIP12,RICTOR,PHC2,FASLG,SCUBE3,MYO5B,BLOC1S2,SMIM3,NCK1 |
| ATP binding | CDK15,IPPK,NEK9,CARS,PIP5KL1,ABCD3,STK25B,NAIP6,PSMC4,FGFR1 |
| protein tyrosine kinase activity | BCR,FGFR1B,FYNB,PTK2AB,JAK2A,DSTYK,MATK,IGF1RA,LYN,MAP3K11 |
| protein serine/threonine kinase activity | DYRK3,TESK2,PRKD2,RIPK4,TP53RK,TRIO,TGFBR1B,PHKG2,TTBK2,AKT3A |
| protein serine/threonine/tyrosine kinase activity | DYRK1AA,RPS6KB1,TTK,CLK1,CLK4,DYRK3,AKT1,RPS6KA1,TNK2,DYRK1B |
Interacting Protein
CLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK2.
CLK3;RBM39;SNIP1;YWHAG
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