CLEC4A
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Official Full Name
C-type lectin domain family 4, member A -
Overview
A member of the calcium-dependent (C-type) lectin receptor (CLR) family, DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM). A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis shows that DCIR mRNA is predominantly transcribed in hematopoietic tissues. DCIR displays a typical lectin CRD and is expressed on DCs, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DCs derived from blood monocytes cultured with GM-CSF and IL-4. DCIR is preferentially expressed by monocyte-related rather than Langerhans cell related DCs obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF- . Thus, DCIR is differentially expressed on DCs depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by antigen-presenting cells, and of potential importance in regulation of DC function. -
Synonyms
DCIR;LLIR;DDB27;CLECSF6;HDCGC13P;C-type lectin domain family 4 member A;C-type lectin DDB27;lectin-like immunoreceptor;dendritic cell immunoreceptor;C-type lectin superfamily member 6;C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6;OTTHUMP00000239071;OTTHUMP00000239070;OTTHUMP00000239052;CLEC4A
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- HEK293
- Wheat Germ
- Human Cells
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- Fc
- His&Myc&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLEC4A-3353H | Recombinant Human CLEC4A protein(Gln70-Leu237), His-tagged | HEK293 | Human | His | 70-237 a.a. | |
| CLEC4A-1467H | Recombinant Human CLEC4A Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLEC4A-1791R | Recombinant Rhesus Monkey CLEC4A Protein | HEK293 | Rhesus macaque | Non | 70-237 a.a. |
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| CLEC4A-2282HCL | Recombinant Human CLEC4A cell lysate | Human Cells | Human | Non |
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| CLEC4A-1066H | Recombinant Human CLEC4A protein(Gln70-Leu237), hFc-tagged | HEK293 | Human | Fc | Gln70-Leu237 |
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| CLEC4A-110H | Recombinant Human CLEC4A Protein, His-tagged | E.coli | Human | His |
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| CLEC4A-1342M | Recombinant Mouse CLEC4A protein(Gln70-Leu238), His-tagged | HEK293 | Mouse | His | Gln70-Leu238 |
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| CLEC4A-2158HF | Recombinant Full Length Human CLEC4A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 237 amino acids |
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| CLEC4A-2212M | Recombinant Mouse CLEC4A Protein (70-238 aa), His-SUMO-Myc-tagged | E.coli | Mouse | His&Myc&SUMO | 70-238 aa |
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| CLEC4A-796H | Recombinant Human CLEC4A Protein, His-tagged | E.coli | Human | His | Gln70-Leu237 |
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Involved Pathway
CLEC4A involved in several pathways and played different roles in them. We selected most pathways CLEC4A participated on our site, such as C-type lectin receptors (CLRs),Dectin-2 family,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | NCKAP1,CD200,CD200R1,KIF18A,ASB13,TAX1BP1,LAIR1,CTLA4,RNF144B,TNFRSF13C |
| C-type lectin receptors (CLRs) | UBE2V1,TAB1,CLEC4D,ITPR2,CREBBP,MALT1,CLEC6A,IL1B2,AHCYL1,CASP8L1 |
| Innate Immune System | CTSLL,NCKAP1,DEFA5,CLEC4D,CD300LB,NLRP4E,BTR18,BTR06,NLRP4,FCN2 |
| Dectin-2 family | CLEC6A,CLEC4D |
Protein Function
CLEC4A has several biochemical functions, for example, carbohydrate binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4A itself. We selected most functions CLEC4A had, and list some proteins which have the same functions with CLEC4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | OR4D6,ANTXR1,TLR7,OR12D2,SELE,CD300C,GP1BB,FCAMR,TLR2,VIPR1B |
| carbohydrate binding | Clec4n,GFPT1,Chil3,CLEC4F,SI,GFPT2,MLEC,FCN3,KLRC2,GALNT4 |
Interacting Protein
CLEC4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4A.
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesGranulocyte Markers
CD Antigen (Granulocyte Markers)
Macrophage Markers
C-type Lectin Receptors
Dendritic Cell ITIM/ITAM Immunoreceptors
Dendritic Cell Pathogen Recognition/Uptake
C-type Lectin Family
Related Services
Related Products
References
- Ishibashi, M; Morita, N; et al. CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection. ARCHIVES OF VIROLOGY 159:2949-2955(2014).
- Wang, MY; Wang, FP; et al. Mannan-Binding Lectin Inhibits Candida albicans-Induced Cellular Responses in PMA-Activated THP-1 Cells through Toll-Like Receptor 2 and Toll-Like Receptor 4. PLOS ONE 8:-(2013).
