CLCN7

  • Official Full Name

    chloride channel 7

  • Overview

    The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

  • Synonyms

    CLCN7;chloride channel 7;H(+)/Cl(-) exchange transporter 7;CLC 7;CLC7;OPTA2;PPP1R63;protein phosphatase 1;regulatory subunit 63;Chloride channel protein 7;ClC-7;CLCN7_HUMAN;FLJ26686;FLJ39644;FLJ46423;OPTB4;protein phosphatase 1, regulatory subunit 63

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLCN7-11280H Recombinant Human CLCN7, GST-tagged E.coli Human GST C-term-208a.a.
CLCN7-1422H Recombinant Human CLCN7 Protein, GST-tagged Wheat Germ Human GST
CLCN7-1428R Recombinant Rat CLCN7 Protein Mammalian Cell Rat His
CLCN7-2351C Recombinant Chicken CLCN7 Mammalian Cell Chicken His
CLCN7-3518M Recombinant Mouse CLCN7 Protein Mammalian Cell Mouse His
CLCN7-4750Z Recombinant Zebrafish CLCN7 Mammalian Cell Zebrafish His
CLCN7-7472HCL Recombinant Human CLCN7 293 Cell Lysate HEK293 Human Non
CLCN7-1086R Recombinant Rat CLCN7 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CLCN7-1086R-B Recombinant Rat CLCN7 Protein Pre-coupled Magnetic Beads HEK293 Rat
CLCN7-1722M Recombinant Mouse CLCN7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CLCN7-1722M-B Recombinant Mouse CLCN7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    CLCN7 involved in several pathways and played different roles in them. We selected most pathways CLCN7 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport ANO5B,CLCN2,TRPC4APA,ANO8,ATP13A,SGK2,ATP2C1,ANO6,TRPC4,TSC22D3
    Transmembrane transport of small molecules SLC39A10,ATP1A1A.3,SLC7A8A,SLC10A6,AQP1A.1,SLC28A3,SLC7A6,ANO5B,ATP1A1A.2,CLCN2
    Stimuli-sensing channels WNK2,SGK2,TRPC4A,TRPM1B,TRPM6,SLC9A10,BEST3,TPCN1,CLCN1A,ANO6

    Protein Function

    CLCN7 has several biochemical functions, for example, ATP binding,antiporter activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN7 itself. We selected most functions CLCN7 had, and list some proteins which have the same functions with CLCN7. You can find most of the proteins on our site.

    Function Related Protein
    voltage-gated chloride channel activity CLCN5,CLCN1,CLCN4-2,CLCN3,CLCN4,CLCNKA,CLCN1A,ANO6,CLCN2,CLCN6
    ATP binding MAP4K6,OASL,DDX43,MCCC1,KDRL,MAP2K4B,CAMK2D2,PRKCG,KIF9,PFKFB2
    antiporter activity SLC9A6A,TMCO3,SLC7A14,SLC25A16,SLC7A5,SLC9A9,TMEM241,SLC35E1,SLC9A5,SLC35C2
    chloride channel activity APOL1,GABRA4,CLCN1,BEST1,CLIC3,CLCA2,CLIC2,CLCA3,GABRA2,SLC26A9

    Interacting Protein

    CLCN7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN7.

    CREB3;pi3p;Ktn1;SLC33A1;Kcnk1;Flot1;XRCC3;Atp2a2;ATP6AP2;Rab5c;Bmpr1a;RAB5C;TMEM63B;Nup98;SAMD1;C1qbp;FAM46A;Vps28;Cd2ap;Tmed2

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