CLCN3

  • Official Full Name

    chloride channel, voltage-sensitive 3

  • Overview

    This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    CLCN3;chloride channel, voltage-sensitive 3;chloride channel 3;H(+)/Cl(-) exchange transporter 3;ClC 3;CLC3;chloride channel protein 3;chloride transporter ClC-3;ClC-3;DKFZp564I0463

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Wheat Germ
  • Mammalian Cell
  • E.coli
  • In vitro E. coli expression system
  • HEK293
  • E.coli expression system
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLCN3-1417H Recombinant Human CLCN3 Protein, GST-tagged Wheat Germ Human GST
CLCN3-1426R Recombinant Rat CLCN3 Protein Mammalian Cell Rat His
CLCN3-3514M Recombinant Mouse CLCN3 Protein Mammalian Cell Mouse His
CLCN3-01H Recombinant Human CLCN3 Protein, His-tagged E.coli Human His
CLCN3-0481H Recombinant Human CLCN3 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Human His Full L. 1-818aa
CLCN3-1084R Recombinant Rat CLCN3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CLCN3-1084R-B Recombinant Rat CLCN3 Protein Pre-coupled Magnetic Beads HEK293 Rat
CLCN3-1719M Recombinant Mouse CLCN3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CLCN3-1719M-B Recombinant Mouse CLCN3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL30363HF Recombinant Human H(+)/Cl(-) Exchange Transporter 3(Clcn3) Protein, His-Tagged E.coli expression system Human His Full Length (1-818aa)

    Involved Pathway

    CLCN3 involved in several pathways and played different roles in them. We selected most pathways CLCN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    CLCN3 has several biochemical functions, for example, ATP binding,PDZ domain binding,antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN3 itself. We selected most functions CLCN3 had, and list some proteins which have the same functions with CLCN3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding HSPA9,CKMT1A,TLK1B,DAPK3,CMPK2,ABCA7,MAP2K2A,DDR1,GLUL,MSH5
    nucleotide binding ORC4,HNRNPABA,RBPMS2B,FGFR1A,CSF1RA,LEMD3,RMI1,NCL,CELF3,EEF2A.2
    PDZ domain binding ARHGAP29,PLEKHA1,SRR,KCNJ4,GRM7,SLC26A6,GIPC1,DTNA,CADM1,ERC1
    protein heterodimerization activity DRAP1,TXLNG,H2BFWT,SOX4,CRLF1,NOTCH1,PIK3R2,TFDP3,VEGFB,CEBPA
    voltage-gated chloride channel activity CLCN1,CLCN6,CLCN2,CLCNKA,CLCNK,CLCN4-2,CLCN1A,CLCN4,ANO6,CLCN5
    ion channel activity TRPC6A,KCNC1B,CHRNB1L,KCNH2A,KCNH1B,CLCN6,P2RX3B,TRPM1,KCNC2,TRPV2
    voltage-gated ion channel activity CLIC5B,NALCN,KCNV2,KCNK7,KCNJ1A.5,PKD2,KCNIP1,CLIC6,KCNJ1A.2,CACNG7A
    chloride channel activity CLCA3,SLC26A3,CLCA1,FXYD3,CLCC1,CLIC1,CLIC2,GABRP,CLCN1,SLC26A6
    antiporter activity TMCO3,SLC7A8,SLC7A3,SLC35E4,SLC9A5,SLC7A14,SLC35E2,CLCN4,Slc4a2,SLC4A8

    Interacting Protein

    CLCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN3.

    Ywhae

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